Mechanisms of Discogenic Pain. Irritation of nerve endings in outer third of the annulus (Bogduk J Anat 1981)Mechanoreceptors are present in outer posterolateral portion of the lumbar disc Sensitization of nociceptors in chronic discogenic pain. (Burke JBJS 2002)In-growth of granulation tissue and small unmyelinated nerve fibers are present in degenerative disc. (Freemont AJ Lancet 1997)Nerve root irritation in full thickness tearsIncreased shear stress across annular wall.
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