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Biological Science to Working FRAMES 2.0 Model

Biological Science to Working FRAMES 2.0 Model. Workshop U.S. Nuclear Regulatory Commission Rockville, Maryland Pacific Northwest National Laboratory November 15-17, 2005. VRT. PBPK. Sources of PM Emissions (Burning of Fossil Fuels). Environmental Fate & Transport. Atmospheric

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Biological Science to Working FRAMES 2.0 Model

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  1. Biological Science to Working FRAMES 2.0 Model Workshop U.S. Nuclear Regulatory Commission Rockville, Maryland Pacific Northwest National Laboratory November 15-17, 2005

  2. VRT PBPK Sources of PM Emissions (Burning of Fossil Fuels) Environmental Fate & Transport Atmospheric Chemistry Biological Modeling Biological models developed and linked within FRAMES Soil Diesel Engine Biological Receptor (Sensitive Populations) Gas Engine Atmospheric Transformations Atmosphere Coal Power Plant Water VCell Biological Modeling Core FRAMES focuses on Source-to-Dose-to-Biological models, and their interrelationships Outcomes Analysis Biologically Based Modeling 2

  3. Lab-level Research and Development • Question: Can the FRAMES integration method be compatible with modern System-Biology scientific knowledge? • Simulation is common but not with tools like FORTRAN but with tools like MatLab, Mathematica, Maple, and SciLab. • Why Scilab? Free for non-commercial use and as powerful as MatLab. 3

  4. The Model is from a Publication • CL Tran, M Graham, D Bucahanon (2000) • Institute of Occupational Medicine • 8 Roxburgh Place, Edinburgh, EH8 9SU, UK • 44(0) 131 667 5131 publications@iomhq.org.uk • sent to JGT 03/05 via email 4

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  6. A couple of command will plot one of the state variables from the system of equations

  7. The plots produced from a couple of simple commands for plots

  8. To connect to FRAMES we • need to either: • provide file that can be • written by FRAMES, • 2) have FRAMES write values to the script directly using tools like BPP, or • 3) have a library set written for the specific tool to facilitate use in the environment (equivalent to a language specific interface). • For the purpose of this • demonstration we use #1. We still need at least some Java code to make it work. 8

  9. Now the module can be used in tandem with an air source, and a lung deposition model from CIIT. The output of the lung deposition is written to the input of cell model.

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