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A14 month old child with Seizure

A14 month old child with Seizure. Dravet syndrome. History. A 14 m lod child referred to our hospital with uncontrolled seizure.It was Partial and hemiclonic and duration was 3-4 minutes.He had fever( lowgrade )and symptoms of a viral infection.(Cough- Coriza ) PMH:

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A14 month old child with Seizure

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  1. A14 month old child with Seizure Dravet syndrome

  2. History • A 14 m lod child referred to our hospital with uncontrolled seizure.It was Partial and hemiclonic and duration was 3-4 minutes.He had fever(lowgrade)and symptoms of a viral infection.(Cough-Coriza) • PMH: • Product of C/S with no history of Asphyxia –Icter or truama.At 2month of age he had a seizure after vaccination.He discharged without any medication.At 6 month of age an dafter vaccination he had a seizure again and Pb prescribed for him.He was seizure free for 9 month.

  3. FH: Parents aren't relative. Positive history of seizure is seen in his uncle. • Development: Normal till 6 m.

  4. DRUGS & Treatments • Phenobarbital wasn't effective. • Pb +PHTnot effective • Seizures became serial and to status • Midazolam(drip) was not effective • Sodium valproate+topiramate(+Carnitine) adminstered.Not effective • Propofole used for him.(Not effective) • Nesdonal Controlled

  5. We start tapering of Nesdonal and add Phenobarbital to ourdrugs (PB+TOPIRAMATE+CLOBAZAM)

  6. Mutations in Dravet • SCN1A • SCN1B • PCDH19(protocadherin 19) • GBRG2

  7. Treatment

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