toxicology PowerPoint PPT Presentation

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History of Toxicology. Poisons Popular in AntiquityEbers Papyrus (Hemlock, Aconite, Opium, Lead, Copper, Antimony)Book of Job (Poison Arrows)Hippocrates (Bioavailability, Above all do no harm)Theophrastus (Poisonous Plants)Dioscorides (Plant, Animal, Mineral)Mithradates (Antidotes)Sulla wrote Lex Cornelia (Law against Poisoning).

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1. Toxicology Session One History

3. History of Toxicology Middle Ages Romeo and Juliet Death Scene Maimonides (Treatment of Poisoning, 1198) Catherine de Medici (Volunteer work to study Onset of Action, Potency, Clinical Signs and Symptoms)

4. History of Toxicology Age of Enlightenment Philippus Aureolus Theophrastus Bombastus Von Hohenheim a/k/a Paracelsus Swiss Physician (Basle) and Austria All substances are poisons; there is none which is not a poison. The right dose differentiates a poison from a remedy. Experiment to know effects/actions Therapeutic dose versus Toxic dose Dose makes the difference Specificity of action

5. History of Toxicology Ellenborg Mercury and lead toxicity from Goldsmithing Agricola Diseases of Miners Ramazzini Discourse on the Diseases of Workers Miners to Midwives, Printers, Weavers and Potters Percival Pott Soot and Scrotal Cancer in Chimney Sweeps

6. History of Toxicology Magendie Experimental physiology and toxicology, emetine and strychnine; absorption and distribution Orfila Laboratory analysis and autopsy, toxicology of natural agents Bernard Arrow Poisons, Curare, Carbon Monoxide, Experimental Medicine

7. History of Toxicology Oswald Schmiedeberg Training of Toxicologists Louis Lewin Studies on the toxicology of narcotics, methanol, glycerol, acrolein, chloroform

9. The Present Day Toxic Substances Control Act (TSCA) Occupational Safety and Health Act (OSHA) More to come from Dr. Sussman

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