1 / 4

Translational Informatics Applied to Drug Safety (TrIADS)

Translational Informatics Applied to Drug Safety (TrIADS). Richard D. Boyce, PhD Assistant Professor Department of Biomedical Informatics University of Pittsburgh Faculty, Center for Pharmaceutical Policy and Prescribing

ctrevino
Download Presentation

Translational Informatics Applied to Drug Safety (TrIADS)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Translational Informatics Applied to Drug Safety (TrIADS) Richard D. Boyce, PhD Assistant Professor Department of Biomedical Informatics University of Pittsburgh Faculty, Center for Pharmaceutical Policy and Prescribing Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program

  2. A new paradigm for drug-drug interaction evidence and knowledge NLM R01LM011838 Dynamic enhancements Scientific literature Product labeling Semantic annotation pipeline Knowledge curation Aim 1 • Data driven: • Synthesis of public PDDI sources • Expert: • Web-based scientific discourse A framework for representing PDDI assertions and evidence as interoperable Linked Data available for community annotation Aim 2 Aim 3 More efficient synthesis of PDDI evidence, easier identification of gaps Reduced risk of a PDDI medication error! • Expected benefits: • More complete and accurate PDDI evidence • Better informed pharmacists and other clinicians • More effective PDDI alerting and decisions support systems

  3. Interventions that improve drug safety for older adults NIA K01AG044433 Automated Observational Health Data Sciences and Informatics (OHDSI) LAERTES project Patient Specific Actionable

  4. Research and Clinical Impact • Google scholar h-index: 10 • Selected Publication • Boyce RD, Collins C, Horn J, Kalet I. Computing with evidence part II: an evidential approach to predicting metabolic drug-drug interactions, Journal of Biomedical Informatics, 2009 Dec;42(6):990-1003. PMCID : PMC2783683 • Boyce RD, Horn JR, Hassanzadeh O, de Waard A, Schneider J, Luciano JS, Rastegar-Mojarad M, Liakata M. Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness. J Biomed Semantics. 2013 Jan 26;4(1):5. DOI 10.1186/2041-1480-4-5 PMID: 23351881. PMCID – PMC3698101 • Boyce. RD., Ryan. PB., Noren. N., et al., Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest. Drug Safety. 2014. Volume 37, Issue 8 (2014), Page 557-567. DOI: 10.1007/s40264-014-0189-0, PubMed PMID: 24985530. PMCID: PMC4134480. • Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M, Dumontier M, Boyce RD, Toward a complete dataset of drug-drug interaction information from publicly available sources, Journal of Biomedical Informatics. 55 (2015), 206-217. DOI:10.1016/j.jbi.2015.04.006. PMCID: PMC4464899. • Inventions • “Pharmacogenomics Information System”, University of Pittsburgh Invention Disclosure Number 03041. 2013 • “An automated multifactorial patient-specific fall risk intervention designed for the nursing home setting that includes consideration of potential drug-drug interactions”, University of Pittsburgh Invention Disclosure Number: 03647. 2015

More Related