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NTP Radioisotopes SOC Ltd A subsidiary of Necsa Ltd Pelindaba, South Africa NTP’S ROLE IN NUCLEAR MEDICINE GLOBALLY A

NTP Radioisotopes SOC Ltd A subsidiary of Necsa Ltd Pelindaba, South Africa NTP’S ROLE IN NUCLEAR MEDICINE GLOBALLY AND COOPERATION WITH BELGIUM www.ntp.co.za. Mapula Letsoalo 2013 October 23. Depleted Uranium Fabrication Facility (Pelindaba). NTP Radioisotopes (Pty) Ltd. Contents

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NTP Radioisotopes SOC Ltd A subsidiary of Necsa Ltd Pelindaba, South Africa NTP’S ROLE IN NUCLEAR MEDICINE GLOBALLY A

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  1. NTP Radioisotopes SOC Ltd A subsidiary of Necsa Ltd Pelindaba, South Africa NTP’S ROLE IN NUCLEAR MEDICINE GLOBALLY AND COOPERATION WITH BELGIUM www.ntp.co.za Mapula Letsoalo 2013 October 23

  2. Depleted Uranium Fabrication Facility (Pelindaba) NTP Radioisotopes (Pty) Ltd • Contents • Role in global Mo-99 supply • Role in SA nuclear medicine • Continued relations with IRE

  3. Geographical Location of NTP Radioisotopes Geographical Location of NTP Radioisotopes Pretoria NTP located at the Necsa Pelindaba Site OR Tambo Soweto Johannesburg

  4. The Real And Lasting Victories Are Those Of Peace In 1991, the South African government signed the Non-Proliferation Treaty (NPT) and became the first and only nation to voluntarily declare and dismantle its nuclear weapons And they shall beat their swords into ploughshares ... – Isaiah 2:4

  5. Mo-99 Production & Related Facilities 5 3 1 4 2 • - Radiochemical Production Plant • - Commercial Office • - Radiopharmaceutical Production Plant • - RadioanalyticalLabs • - SAFARI-1

  6. SAFARI-1 Nuclear Reactor SAFARI-1 Reactor

  7. Mo-99 Production at NTP Mo-99 Production at NTP SAFARI-1 Reactor Target Plate Irradiation Nuclear Fuel Assemblies Fuel Production Plant Enriched UraniumInventory Target Plates Irradiated plates DepletedUranium Inventory Waste Nuclear Waste Management Radiochemical Production Plant Chemical Extraction and purification of Mo-99 Waste Disposal & Storage Facilities Transport Container DesignManufacture, License NTP Generator Manufacture International Market Local & International Users

  8. NTP Product Portfolio NTP - IRE Cooperation • Collaborative partnership since 1997 • Mo-99 Supply crisis • Increased production output • Total: 8 000 Ci/week

  9. Radioisotope Source Containers Radioisotope Source Containers Depleted uranium fabrication facility Radiochemical Transport Containers (1 500 Ci Mo-99, 125kg)

  10. Subsidiary Companies Subsidiary Company • NTP Logistics is a joint venture company between NTP Radioisotopes (51 %) and a BEE partner • Specialize in managing the logistics of dangerous goods including radioactive materials.

  11. NTP Product Portfolio • Conversion of Mo-99 Production to LEU

  12. Medicals Facilities Medical Facility 3 3 2 2 • - Medicals & Industrials • - SAFARI-1 • - Cyclotron facility 1 1

  13. Nuclear Medical Isotopes & Related Products Radiopharmaceuticals • Radiopharmaceuticals • NovaTec-P Tc-99m Generator, Cold kits • F-18 FDG • I-131 Capsules, Solution and MIBG • New • Lu-177 dotatate • F-Choline PET-CT Image

  14. Subsidiary Companies Subsidiary Company • NTP has a 100% shareholding in AEC-Amersham SOC Ltd • Exclusive distributor in Africa of NTP's radiopharmaceutical products as well as a range of life science research and other products.

  15. Corporate Social Investment • PET/CT Scanner donated to people of Western Cape • Located at Tygerberg PET/CT Centre • Official opening - April 2012

  16. Subsidiary Companies Subsidiary Company • Fully-owned subsidiary company NTP Radioisotopes (Europe) S.A. • Established on 1 February 2013 • Located in Belgium– IRE site • Manufacturer and distributor of gamma-radiography equipment used in the non-destructive testing (NDT) industry, including sealed radioactive sources containing Ir-192, Se-75 and Co-60, as well as the GammaMat range of NDT projectors and accessories • Also manufactures a range of Ir-192 brachytherapy products

  17. Subsidiary Companies Conclusion Necsa/ NTP’s nuclear technology is making a major contribution to the economy and to our country’s global standing.

  18. Subsidiary Companies Thank you very much!

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