1 / 48

PERIPHERAL NEUROPATHY

PERIPHERAL NEUROPATHY. PHYSIOLOGY. Pain and temperature sensation : unmyelinated and small myelinated A d fibers, Vibratory sense, proprioception, and the afferent limb of the tendon reflex : large myelinated A a and A b fibers. Light touch : both large and small myelinated fibers.

cruze
Download Presentation

PERIPHERAL NEUROPATHY

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. PERIPHERAL NEUROPATHY

  2. PHYSIOLOGY • Pain and temperature sensation : unmyelinated and small myelinated Ad fibers, • Vibratory sense, proprioception, and the afferent limb of the tendon reflex : large myelinated Aa and Ab fibers. • Light touch : both large and small myelinated fibers.

  3. FIVE QUESTION APPROACH 1. Fiber type 2. Pattern of distribution 5. Pathology 3. Temporal course 4. Key features

  4. 1.What is the fiber type involved? (motor, large sensory, small sensory, autonomic, combination) • 2. What is the pattern of distribution? (distal or proximal, symmetric or asymmetric) • 3. What is the temporal course? (acute, chronic, progressive, stepwise, relapsing remitting) • 4. Are there any key features pointing to a specific etiology? (toxic/nutritional/malignancy) • 5. What is the pathology? (axonal, demyelinating)

  5. Pathological Process • (1) Wallerian degeneration, which is the response to axonal interruption; • (2) Axonal degeneration or axonopathy; • (3) Primary neuronal degeneration or neuronopathy; • (4) Segmental demyelination

  6. Wallerian degeneration • Any type of mechanical injury that causes interruption of axons leads to wallerian degeneration (degeneration of axons and their myelin sheaths) distal to the site of transection.

  7. Axonal degeneration • Most common pathological reaction of peripheral nerve • Caused by :Systemic metabolic disorders, toxin exposure, and some inherited neuropathies • Also called dying-back or length-dependent neuropathy: • The myelin sheath breaks down along with the axon in a process that starts at the most distal part of the nerve fiber and progresses toward the nerve cell body.

  8. Dying-back neuropathy • Clinically, presents with symmetrical, distal loss of sensory and motor function in the lower extremities that extends proximally in a graded manner. • The result is sensory loss in a stocking-like pattern, distal muscle weakness and atrophy, and loss of ankle reflexes

  9. Neuronopathy • Primary loss or destruction of nerve cell bodies with resultant degeneration of their entire peripheral and central axons. • Either lower motor neurons or dorsal root ganglion cells may be affected. • When anterior horn cells - poliomyelitis or motor neuron disease: focal weakness without sensory loss • Sensory neuronopathy, or polyganglionopathy :damage to dorsal root ganglion neurons - inability to localize the limb in space, diffuse areflexia, and sensory ataxia.

  10. Segmental demyelination • The term implies injury of either myelin sheaths or Schwann cells, resulting in breakdown of myelin with sparing of axons • This occurs in immune-mediated demyelinating neuropathies and in hereditary disorders of Schwann cell/myelin metabolism.

  11. Demyelinating neuropathies • Relative sparing of temperature and pinprick sensation + • 1.Early generalized loss of reflexes, 2.disproportionately mild muscle atrophy 3.presence of proximal and distal weakness, 4.neuropathic tremor 5. palpably enlarged nerves

  12. Diagnostic Clues from the History • 1.motor 2.sensory 3.autonomic disturbances. Seek both positive and negative symptoms. • A. Motor: • Positive : Muscle cramps, fasciculations, myokymia, or tremor • Negative : early distal toe and ankle extensor weakness, resulting in tripping on rugs or uneven ground

  13. Sensory symptoms Positive : • prickling, searing, burning, and tight bandlike sensations. • Paresthesia: Unpleasant sensations arising spontaneously without apparent stimulus • Allodynia: perception of nonpainful stimuli as painful. • Hyperalgesia: Painful hypersensitivity to noxious stimuli • Neuropathic pain: cardinal feature of many neuropathies.

  14. Autonomic dysfunction • Orthostatic lightheadedness, • Fainting spells, • Sweating reduced or excessive, • Heat intolerance, • Bladder, Bowel, and Sexual dysfunction. • Anorexia, early satiety, nausea, and vomiting

  15. TEMPORAL CLUES • Onset, duration, and evolution of symptoms • Tempo of disease : acute, subacute, or chronic • Course: monophasic, progressive, or relapsing • Acute presentations: Guillain-Barré syndrome (GBS), acute porphyria, vasculitis, toxic neuropathies. • Relapsing course : (CIDP), acute porphyria, Refsum's disease, hereditary neuropathy with liability to pressure palsies (HNPP), familial brachial plexus neuropathy, and repeated episodes of toxin exposure.

  16. DM hypothyroidism chronic renal failure liver disease intestinal malabsorption malignancy connective tissue diseases [HIV] drug use Vitamin B6 toxicity alcohol and dietary habits exposure to solvents, pesticides, or heavy metals. Constitutional symptoms • Weight loss, malaise, and anorexia.

  17. Mononeuropathy • Focal involvement of a single nerve and implies a local process: • Direct trauma • compression or entrapment • vascular lesions • neoplastic compression or infiltration

  18. Mononeuropathy multiplex • simultaneous /sequential damage to multiple noncontiguous nerves. • Ischemia caused by vasculitis • Microangiopathy in diabetes mellitus • Less common causes : Infectious, granulomatous, leukemic, or neoplastic infiltration, Hansen's disease (leprosy) and sarcoidosis.

  19. Polyneuropathy • Characterized by symmetrical, distal motor and sensory deficits that have a graded increase in severity distally and by distal attenuation of reflexes, • Rarely predominantly proximal:(E.g: acute intermittent porphyria). • The sensory deficits generally follow a length-dependent stocking-glove pattern

  20. Motor deficits Dominate the clinical picture in • 1. AIDP/CIDP • 2. Hereditary motor and sensory neuropathies, • 3. Neuropathies associated with osteosclerotic myeloma, porphyria, lead and organophosphate intoxications, and hypoglycemia.

  21. Pattern of weakness • Asymmetrical motor weakness without sensory loss suggests motor neuron disease or multifocal motor neuropathy with conduction block

  22. Neuropathies with Facial Nerve Involvement • Guillain-Barré syndrome • Chronic inflammatory polyradiculoneuropathy   • Lyme disease • Sarcoidosis • HIV    

  23. Diabetes Carcinoma; Sjögren's syndrome; Dysproteinemia; AIDS vitamin B12 deficiency Celiac disease Toxicity with cisplatin, thalidomide, or pyridoxine Inherited and idiopathic sensory neuropathies Predominant Sensory

  24. Autonomic dysfunction • GBS • Diabetes • Amyloid sensorimotor polyneuropathy

  25. Small-Fiber Neuropathies  • Idiopathic small fiber neuropathy • Diabetes mellitus • Amyloid neuropathy    • HIV-associated distal sensory neuropathy • Hereditary sensory and autonomic neuropathies

  26. Large-fiber • Areflexia • Pseudoathetosis • Loss of joint position and vibration sense • Positive Romberg's sign

  27. Electrodiagnostic studies • (1) Confirming the presence of neuropathy, • (2) Locating focal nerve lesions, • (3) Nature of the underlying nerve pathology

  28. Distal motor latency prolonged Nerve conduction velocity slow Reduced action potential

  29. Nerve biopsy • In vasculitis, amyloid neuropathy, leprosy, CIDP, Inherited disorders of myelin, and rare axonopathies • The Sural nerve is selected most commonly • The superficial peroneal nerve – alternative; :advantage of allowing simultaneous biopsy of the peroneus brevis muscle through the same incision. • This combined nerve and muscle biopsy procedure increases the yield of identifying suspected vasculitis

  30. Neuropathies + Serum Autoantibodies Antibodies against Gangliosides • GM1 : Multifocal motor neuropathy • GM1, GD1a : Guillain-Barré syndrome • GQ1b : Miller Fisher variant Antibodies against Glycoproteins • Myelin-associated glycoprotein : MGUS Antibodies against RNA-binding proteins • Anti-Hu, antineuronal nuclear antibody 1: Malignant inflammatory polyganglionopathy

  31. SUMMARY • A.Clinical pattern of neurologic findingsPolyneuropathy, Neuronopathy, Mononeuropathy, Multiple mononeuropathy, Plexopathies • B.Functional disturbance: Motor, Sensory, Autonomic, Mixed • C.Mode of onset : • 1.Acute 2.Subacute 3.Chronic 4.Relapsing

  32. D.Pathological and electrophysiological criteria: • 1.Demyelinating disease vs Axonopathy • 2.Wallerian degeneration - trauma • 3.Dying back neuropathy - toxic, metabolic • E.Etiology: • Metabolic, immune mediated, toxic, vasculitis, dysproteinemic, inherited, Nutritional deficiency

  33. F.Diagnosis • 1.Clinical data • 2.Electrophysiologic test : NCS, EMG • 3.Biochemical test : metabolic, nutritional, toxic • 4.CSF study • 5. Nerve & muscle biopsy • 6.Measurement of Ig & anti-neural antibody • 7.Genetic study

More Related