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Pedigrees

Pedigrees. Complex Inheritance Patterns: Autosomal v. X-Linked. Family Tree Genealogy Inheritance Diagram Relates parents and offspring for numerous generations Shows relationships between parents, children, grandchildren… Aunts, uncles; cousins; second-cousins; distant relatives

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Pedigrees

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  1. Pedigrees Complex Inheritance Patterns: Autosomal v. X-Linked

  2. Family Tree • Genealogy • Inheritance Diagram • Relates parents and offspring for numerous generations • Shows relationships between parents, children, grandchildren… • Aunts, uncles; cousins; second-cousins; distant relatives • Are useful in tracking complex inheritance traits, genetic disorders, and sex-linked traits Pedigree

  3. Female: Circle • Male: Square • Line between: Parental relationship • Line down: Parent to children • Line over and connecting: Siblings • Chronological order: Left to Right • Left (oldest) to right (youngest) • Dashed Line: Same person • Shading: Carries/has specific trait How to make a pedigree

  4. TibbotCsik (bb) Dottie Csik (Bb) Jerry Vessey (bg) Diane Vessey (gg) Terry Csik (Bb) Paul Csik (Bb) Phil Csik (Bb) Steven Csik (bb) Cindy Csik (bb) Phil Csik (Bb) GenellCsik (gg) Corinne Popke (bg) My Pedigree: Eye Color Kirstin Csik (Bg) Nick Csik (Bg)

  5. Please get out Investigation 18: Punnett Square Practice • We already did Parts A, B and C last week • SKIP the Analysis Questions • Do Part D now Let’s Practice!

  6. Using Pedigrees Solving problems for Sex-linked traits, genetic disorders and unknown inheritance

  7. A “sex-linked” trait is carried on one of the sex chromosomes • X-linked traits are far more common in men than women • Tracking sex-linked traits, particularly when determining if women are carriers, requires use of Pedigrees Sex-linked traits

  8. Autosomes • 22 homologous chromosome pairs • Autosomal traits occur on one or more of your AUTOSOMES • Sex Chromosomes • Sex-linked traits occur on a X or Y • Female: XX • Male: XY Autosomal v. X-Linked

  9. Albinos http://www.animaltalk.us/albino-animals/

  10. Albino: Latin root meaning “white” • Lack of pigment: no colors • Autosomal, Recessive trait AA=Normal Aa=Carrier aa=Albino Autosomal Inheritance: Albinism

  11. Ocular: Latin root meaning “Eye” • Lack of pigment in eyes only • X-Linked, Recessive trait XX=Normal Xx=Carrier xx=Ocular Albino XY=Normal xY=Ocular Albino X-Linked Inheritance: Ocular Albinism http://www.scientificamerican.com/article.cfm?id=cosmetics-animal-testing

  12. http://ocw.tufts.edu/Content/51/lecturenotes/551169/551383

  13. Genetic bleeding disorder: No clotting factor • IF you have hemophilia: • No clotting proteins to work with platelets • Recessive • Rare disease • X-Linked • More common in males • VERY rare in females Hemophilia http://www.zimbio.com/Hemophilia/articles/Tds3gpcOOph/Hemophilia+Disease

  14. We will be taking on roles today to help solve the mystery of the Russian Royal family, and the would-be heir: Alexei Romanova • We will construct a pedigree of the Victorian-era royal family to help us investigate the mysterious deaths of royals The Romanova Mystery

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