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Components controlling structure & function of DNA

AIDA and Semantic Web for epigenetics hypothesis formation Marco Roos, M. Scott Marshall, Andrew P. Gibson, Pieter W. Adriaans SWAT4LS, Edinburgh, November 28, 2008. Components controlling structure & function of DNA. Decondensed chromatin. Histone methylation at H3K9. HDAC. HAT.

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Components controlling structure & function of DNA

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  1. AIDA and Semantic Web for epigenetics hypothesis formationMarco Roos, M. Scott Marshall, Andrew P. Gibson, Pieter W. AdriaansSWAT4LS, Edinburgh, November 28, 2008

  2. Components controlling structure & function of DNA

  3. Decondensed chromatin Histone methylation at H3K9 HDAC HAT Histoneacetylation DNA methylation Condensed chromatin Extending my biological model

  4. My brain is too small!

  5. * My ws Your ws My ws My ws Your ws Empower me with a ‘virtual brain’ * From P.J. Verschure, Journal of Cellular Biochemistry 2006, vol. 99(1), pg 23-34

  6. Workflow and Semantic Web Query Add query to semantic model Retrieve documents from Medline Add documents (IDs) to semantic model Extract gene or protein names Add proteins to semantic model Extract gene or protein interactions Add gene or protein interactions to semantic model Calculate ranking scores Add scores to semantic model Create biological cross references Add cross references to semantic model Convert to table (html)

  7. Separation of models and instances in OWL

  8. AIDA and Semantic Web for epigenetics hypothesis formationMarco Roos, M. Scott Marshall, Andrew P. Gibson, Pieter W. AdriaansSWAT4LS, Edinburgh, November 28, 2008

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