1 / 9

Cancer

P. Perera Science 1997 278:1068. polycyclic aromatic Hydrocarbons PAH. Cancer. Environment. Susceptibility. Genes. P450, glutathione S-transferase (GST) N -acetyltransferase (NAT). Cancer prevention : a Life Course Approach. Older ages. Infancy and Childhood. Adult Life. Adolescence.

ciel
Download Presentation

Cancer

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. P. Perera Science 1997 278:1068 polycyclic aromatic Hydrocarbons PAH Cancer Environment Susceptibility Genes P450, glutathione S-transferase (GST) N-acetyltransferase (NAT)

  2. Cancer prevention : a Life Course Approach Older ages Infancy andChildhood Adult Life Adolescence FetalLife Development of Cancer Accumulated risk Genetic susceptibility to Cancer Age

  3. http://archive.ewg.org/reports/bodyburden2/ Umbilical cord blood from newborns found an array of industrial chemicals, pesticides and pollutants. Ten newborns averaged 200 contaminants, and 209 pollutants had never before been detected in cord blood. Of the 287 chemicals found in newborn umbilical cord blood, 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause developmental problems. The dangers of exposure to these chemicals in combination has never been studied.

  4. http://archive.ewg.org/reports/bodyburden2/ • Of the 287 chemicals found in newborn umbilical cord blood, 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause developmental problems. The dangers of exposure to these chemicals in combination has never been studied. • We detected 287 chemicals of 413 tested (69 percent) in umbilical cord blood samples from 10 newborn babies, with a range of between 154 and 231 for each child. We found 101 chemicals in all babies tested. organochlorine pesticides (DDT/ dieldrin) chemicals in a wide range of consumer products (perfluorochemicals, brominated fire retardants, PCBs), and chemicals from waste incineration and fossil fuel combustion (polyaromatic hydrocarbons, polychlorinated and polybrominated dioxins/furans, polychlorinated naphthalenes, mercury).

  5. Endocrine disruptors during breast development Synthetic halogenated chemicals increase liver tumors after early life-stage exposure. TCDD a prototypical endocrine-disrupting compound, 2,3,7,8-tetra chloro dibenzo-p-dioxin, has been shown to be a developmental toxicant of the mammary gland in rodents. Dioxin alters multiple endocrine systems, and its effects on the developing breast involve delayed proliferation/differentiation of the mammary gland, as well as an elongation of the window of sensitivity to potential carcinogens. Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection. Birnbaum SLEnviron Health Perspect 111:389–394 (2003).

  6. Endocrine disruptors during breast development TCDD 1 mg/kg ATR 100mg/kg Control atrazine dioxin PND 4 PND 33 PND 68 Mammary gland tissue from LE rats exposed in late gestation to ATR is atrazine ( a pesticide) and TCDD or 2,3,7,8-tetrachlorodibenzo-p dioxin. Birnbaum SLEnviron Health Perspect 111:389–394 (2003).

  7. Mortalidad por tumores malignos de mama* Chile 1990-2004. Tasas por 100.000 *femenino Fuente: DEIS/MINSAL

  8. Mortalidad por tumores malignos de próstata Chile 1990-2004. Tasas por 100.000 Fuente: DEIS/MINSAL

More Related