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2003-2004 Antibiotics Review

2003-2004 Antibiotics Review. 3 January 2020 11:15 PM. Amikacin. Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation. Aminoglycosides. Antibiotics Bactericidal protein synthesis inhibitors 30S ribosome Freeze initiation. Ampicillin.

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2003-2004 Antibiotics Review

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  1. 2003-2004Antibiotics Review 3 January 202011:15 PM

  2. Amikacin • Aminoglycoside antibioticBactericidal protein synthesis inhibitor • 30S ribosomeFreezes initiation

  3. Aminoglycosides • AntibioticsBactericidal protein synthesis inhibitors • 30S ribosomeFreeze initiation

  4. Ampicillin • Penicillin antibioticCell wall synthesis inhibitor • Amino penicillinInhibits peptidoglycan cross-linking

  5. Amphotericin B • AntifungalPolyene antibiotic • Binds to ergosterol and alters permeabilitySystemic

  6. Azithromycin • Macrolide antibioticBacteriostatic protein synthesis inhibitor • 50S ribosome Inhibits translocation

  7. Aztreonam • New b lactam antibiotic • Monobactam

  8. Bacitracin • AntibioticCell wall synthesis inhibitor • Topical, not a b lactam, Inhibits dephosphorylation of bactoprenol

  9. Benzathine penicillin G • Penicillin antibioticCell wall synthesis inhibitor • Inhibits peptidoglycan cross-linking Repository preparation

  10. Carbenicillin • Penicillin antibioticCell wall synthesis inhibitor • Anti-pseudomonal penicillinInhibits peptidoglycan cross-linking

  11. Cefaclor • Cephalosporin antibioticCell wall synthesis inhibitor • 2nd generationOral

  12. Cefadroxil • Cephalosporin antibioticCell wall synthesis inhibitor • 1st generationOral

  13. Cefepime • Cephalosporin antibioticCell wall synthesis inhibitor • 4th generationCSF penetration

  14. Cefotaxime • Cephalosporin antibioticCell wall synthesis inhibitor • 3rd generationCSF penetration

  15. Cefoxitin • Cephalosporin antibioticCell wall synthesis inhibitor • 2nd generation

  16. Ceftazidime • Cephalosporin antibioticCell wall synthesis inhibitor • 3rd generation

  17. Ceftriaxone • Cephalosporin antibioticCell wall synthesis inhibitor • 3rd generationCSF penetration

  18. Cefuroxime • Cephalosporin antibioticCell wall synthesis inhibitor • 2nd generationCSF penetration

  19. Cephalexin • Cephalosporin antibioticCell wall synthesis inhibitor • 1st generationOral

  20. Cephalosporins • Antibioticsb lactam • Cell wall synthesis inhibitorsInhibit cross-linking of peptidoglycan

  21. Cephalothin • Cephalosporin antibioticCell wall synthesis inhibitor • 1st generationOral

  22. Chloramphenicol • AntibioticBacteriostatic protein synthesis inhibitor • 50S ribosomeInhibits peptide bond formation

  23. Ciprofloxacin • Fluoroquinolone antibioticDNA replication inhibitor • Inhibits bacterial DNA gyrase

  24. Clarithromycin • Macrolide antibioticBacteriostatic protein synthesis inhibitor Antiulcer • 50S ribosomeInhibits translocation

  25. Clavulanic acid • b-lactamase inhibitor • Combined with antibacterials

  26. Clindamycin • AntibioticBacteriostatic protein synthesis inhibitor • 50S ribosomeAnaerobic infections

  27. Cloxacillin • Penicillin antibioticCell wall synthesis inhibitor • Penicillinase resistant penicillinInhibits peptidoglycan cross-linking

  28. Cycloserine • AntibioticCell wall synthesis inhibitor • Secondary TB drugInhibits formation of Park nucleotide

  29. Dapsone • Sulfone antibioticNucleic acid andprotein synthesis inhibitor • Inhibits dihydropteroate synthetaseLeprosy

  30. Doxycycline • Tetracycline antibioticBacteriostatic protein synthesis inhibitor • 30S ribosomePrevents aminoacyl tRNA attachment

  31. Erythromycin • Macrolide antibioticBacteriostatic protein synthesis inhibitor • 50S ribosomeInhibits translocation

  32. Ethambutol • Antibiotic • Major drug for tuberculosis

  33. Ethionamide • Antibiotic • Secondary drug for tuberculosis

  34. Fluorinated Quinolonesciprofloxacin, norfloxacin • AntibioticsDNA replication inhibitors • Inhibit bacterial DNA gyrase

  35. Gentamicin • Aminoglycoside antibioticbactericidal protein synthesis inhibitor • 30S ribosomeFreezes initiation

  36. Imipenem/Cilastatin • New b lactam antibiotic • Cilastatin inhibits akidney dipeptidase that inactivates imipenem

  37. Isoniazid • Antibiotic • Inhibits biosynthesis of mycolic acids Major drug for tuberculosis

  38. Linezolid • Oxazolidinone antibioticProtein synthesis inhibitor • 50S ribosomal subunit

  39. Macrolideserythromycin, azithromycin, clarithromycin • AntibioticsBacteriostatic protein synthesis inhibitors • 50S ribosome

  40. Methicillin • Penicillin antibioticCell wall synthesis inhibitor • Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking

  41. Metronidazole • AntibioticAntiparasiticAntiulcer • AnaerobesReduction leads to intermediatesthat damage DNA

  42. Minocycline • Tetracycline antibioticBacteriostatic protein synthesis inhibitor • 30S ribosomePrevents aminoacyl tRNA attachment

  43. Nafcillin • Penicillin antibioticCell wall synthesis inhibitor • Penicillinase resistant penicillinInhibits peptidoglycan cross-linking

  44. Neomycin • Aminoglycoside antibioticBactericidal protein synthesis inhibitor • 30S ribosomeFreezes initiationTopical

  45. Netilmicin • Aminoglycoside antibioticBactericidal protein synthesis inhibitor • 30S ribosomeFreezes initiation

  46. Norfloxacin • Fluoroquinolone antibioticDNA replication inhibitor • Inhibits bacterial DNA gyrase

  47. Nystatin • AntifungalPolyene antibiotic • Binds to ergosterol & alters permeabilityTopical

  48. Oxacillin • Penicillin antibioticCell wall synthesis inhibitor • Pencillinase resistant penicillinInhibits peptidoglycan cross-linking

  49. Oxytetracycline • Tetracycline antibioticBacteriostatic protein synthesis inhibitor • 30S ribosomePrevents aminoacyl tRNA attachment

  50. Para-aminosalicylic acid • AntibioticNucleic acid andprotein synthesis inhibitor • Inhibits dihydropteroate synthetaseSecondary TB drug

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