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2003-2004 Cytokine Review

2003-2004 Cytokine Review. 5 June 2014 8:45 AM. Adalimumab. TNF inhibitor Anti-TNF antibody Used in rheumatoid arthritis. Bradykinin. Inflammatory mediator Plasma, hypotension, pain. C3a, C5a. Inflammatory mediators Anaphylatoxins Low molecular weight complement cleavage products.

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2003-2004 Cytokine Review

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  1. 2003-2004Cytokine Review 5 June 20148:45 AM

  2. Adalimumab • TNF inhibitor • Anti-TNF antibodyUsed in rheumatoid arthritis

  3. Bradykinin • Inflammatory mediator • Plasma, hypotension, pain

  4. C3a, C5a • Inflammatory mediators • Anaphylatoxins Low molecular weight complement cleavage products

  5. Cromolyn sodium • Mast cell stabilizer • Inhibits release ofmast cell mediatorsUsed prophylactically in asthma

  6. Erythropoietin (EPO) • Cytokine • Primary regulator of RBC synthesis

  7. Etanercept • TNF inhibitor • Tumor necrosis factor receptor+ Fc portion of IgGUsed in rheumatoid arthritis

  8. Granulocyte-Colony Stimulating Factor (G-CSF) • Cytokine • Granulocyte synthesis stimulator

  9. Granulocyte/Monocyte-Colony Stimulating Factor (GM-CSF) • Cytokine • WBC (granulocytes and monocyte) synthesis stimulator

  10. Histamine • Inflammatory mediator • Stored in mast cells and basophils

  11. Infliximab • TNF inhibitor • Anti-TNF monoclonal antibodyTreatment of IBD

  12. Interferon alpha • Antiviral for hepatitisAntineoplasticCytokine • Anti-angiogenesis

  13. Interleukin 2 • Cytokine Antineoplastic

  14. Interleukin 11 • Cytokine Antineoplastic (supporting agent)

  15. Kallidin • Inflammatory mediator • Plasma, hypotension, pain

  16. Leukotriene B4 (LTB4) • Inflammatory mediator • Lipoxygenase productof arachidonate metabolismChemotactic

  17. Leukotrienes C4, D4, E4(LTC4,LTD4,LTE4) • Inflammatory mediators • Cysteinyl leukotrienesPeptidyl leukotrienesSRS-ALipoxygenase products ofarachidonate metabolism

  18. Montelukast • Leukotriene inhibitor • LTR1 and LTD4 antagonistAsthma treatment

  19. Nedocromil • Mast cell stabilizer • Inhibits release of mast cell mediatorsUsed prophylactically in asthma

  20. Platelet Activating Factor (PAF) • Inflammatory mediator • LipidHypotensive

  21. Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost) • Oxytocic prostaglandinInflammatory mediator • Cyclooxygenase product of arachidonate metabolismUterine stimulantCervical ripener

  22. Prostaglandin F2 (PGF2) • Inflammatory mediator • Cyclooxygenase product of arachidonate metabolism

  23. Prostaglandin I2 (PGI2) Prostacyclin • Inflammatory mediator • Inhibits platelet aggregationCyclooxygenase product of arachidonate metabolism

  24. Thrombopoietin • Cytokine • Platelet synthesis stimulator

  25. Thromboxane A2 (TXA2) • Autacoid • Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

  26. Tumor necrosis factor  • CytokineAntineoplastic

  27. Zafirlukast • Leukotriene inhibitor • LTR1 and LTD4 antagonistAsthma treatment

  28. Zileuton • Leukotriene inhibitor • 5-lipoxygenase inhibitorUsed in asthma

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