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Career Development Awards (K series) and Research Project Grants (R series)

Career Development Awards (K series) and Research Project Grants (R series). Thomas Mitchell, MA, MPH Department of Epidemiology & Biostatistics University of California San Francisco May 2016. Every fundable K award begins with “a great candidate”. Evidence of recent productivity

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Career Development Awards (K series) and Research Project Grants (R series)

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  1. Career Development Awards (K series) and Research Project Grants (R series) Thomas Mitchell, MA, MPH Department of Epidemiology & Biostatistics University of California San Francisco May 2016

  2. Every fundable K award begins with “a great candidate” • Evidence of recent productivity • At least one first-author publication of original research in a peer-reviewed journal. • A track record of training and research consistent with the mission of your Institute. • Credible plan for achieving independence as an investigator. • A career development plan and a research plan that will prepare you to compete successfully for an R01 grant.

  3. Career development training plans for a K award • Develop a training plan that is uniquely suited to you. • Identify areas where you need additional training to compete successfully for an R01. • Propose a mix of didactic training and “hands- on” research experience that make perfect sense for you (and only you). • Degree-granting programs (e.g., MPH, MAS) are appropriate for candidates with little or no previous formal training in research, but even these programs should be “customized” whenever possible.

  4. Training plans for K awards (cont’d) • A training plan that emphasizes “hands-on” research experience is appropriate for candidates with substantial previous formal training in research. • Reviewers expect you to fully exploit the training resources that are available to you at UCSF. • You can propose to use training resources outside UCSF, but choose the best available. • Your training plan should be as strong as your research plan.

  5. Designing a research plan for a K award application • The research plan is a training vehicle. • The research plan should provide an opportunity to acquire new skills and should be well integrated with your career development training plan. • The research plan is a means to achieve independence. • The research plan should be viewed as a precursor for a subsequent R01 application. • Mentored K awards provide limited funding. • The scope of the research plan needs to be appropriate and feasible, given the modest resources available in a mentored K award.

  6. Developing Specific Aims for a K award • Because a mentored K award is a precursor for a subsequent R01 award, each specific aim should contribute to achieving that goal. • Given the modest resources available in a mentored K award, a “modular” approach is often used, in which several small projects are proposed . • Examples: Secondary analyses of existing data, leveraging ongoing cohort studies or clinical trials, or conducting a small pilot study. • Each project (or specific aim) should provide you with either key preliminary data or an essential skill needed for the R01.

  7. Building your team for a K award • Choose a primary mentor who is a senior investigator with a track-record of NIH funding • Your primary mentor should be at UCSF. • Include co-mentors who will complement the primary mentor’s strengths. • Avoid including co-mentors from institutions outside the Bay Area. • If you include outside members, call them a scientific or technical advisor rather than a co-mentor. • Establish a relatively small (3-5) mentoring team. • Each member of your team should play a role in your training plan.

  8. Choosing the right funding mechanism: K01, K08, or K23? • K01: Mentored Research Scientist Development Award • Some NIH institutes use this award for individuals who propose to train in a new field or to increase research workforce in particular types of research. • K08: Mentored Clinical Scientist Development Award • Clinical training required; not patient-oriented research • K23: Mentored Patient-Oriented Research Career Development Award • Clinical training required; must be patient-oriented research

  9. Every fundable R01 begins with “a great idea” The idea must be creative, exciting, and worth funding. • Concentrate ideas in your area of expertise that would make an impact on public health. • Do your homework; make sure your project fills a gap in the existing literature. • Brainstorm potential ideas with mentors and colleagues in your field.

  10. Designing a research plan for an R01 • Address a clearly defined research problem that is a high priority in your field. • Build on previous research and pose interesting, important, and testable hypotheses. • Propose a scope of work that is appropriate to the track record of the investigator(s).

  11. Building your team for an R01 • Seek opportunities for collaboration. • Identify co-investigators who fill gaps in your expertise, especially a collaborator who is well known. • Consider multidisciplinary approaches. • Recruit senior colleagues who can provide advice and periodicpeer-review of your grant application (e.g., overall scope, specific aims, methods)

  12. The Multiple PI Option If you lack key competencies with regard to the approach you’re proposing in the R01, you might consider the “multiple PI” option. • This option should be used only in circumstances where “team science” is employed. • These projects require 2 or more equally important areas of expertise that are central to the research project. • Recruit an investigator whose expertise complements yours and addresses critical competencies that you lack.

  13. Choosing the right funding mechanism: R01, R03, R21? • R01: Research Project Grant • Definition:“Supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing the investigator's specific interest and competencies, based on the mission of the NIH.” • Funding • 3 - 5 years • Most R01s use “modular budgets” ($250K/year or less in direct costs) • Special permission is required to submit an R01 if any year exceeds $500K/year in direct costs.

  14. Choosing the right funding mechanism: R01, R03, R21? • R03: Small Grant • Definition: Supports small projects that can be carried out in a short period of time with limited resources. • Funding: Up to $100K in direct costs for 2 years ($50K/year) • Appropriate projects • Pilot or feasibility studies • Secondary analysis of existing data • Small, self-contained research projects • Development of research methodology or new research technology

  15. Choosing the right funding mechanism: R01, R03, R21? • R21: Exploratory/Developmental Grant • Provides support for the early or conceptual stages of development. • Funding: Up to $275K in direct costs over 2 years. • Appropriate projects: Should address the feasibility of a novel area of investigationor a new experimental system that has the potential to enhance health-related research. • The NIH parent announcement describes this research as “High Risk – High Impact.” • However, some Institute-specific program announcements may not emphasize this requirement. • Warning!Not all NIH institutes support R21s!

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