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Bioanalytic Techniques with Silicon Chips for Human Healthcare D onhee Ham H arvard University

Bioanalytic Techniques with Silicon Chips for Human Healthcare D onhee Ham H arvard University. Trends in Human Healthcare. Industrialized World. 4P Medicine – Low cost; small size. Early Disease Detection – Extreme sensitivity Ubiquitous Healthcare – Low cost; small size. 3 rd World.

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Bioanalytic Techniques with Silicon Chips for Human Healthcare D onhee Ham H arvard University

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  1. Bioanalytic Techniques with Silicon Chips for Human Healthcare Donhee Ham Harvard University

  2. Trends in Human Healthcare Industrialized World • 4P Medicine– Low cost; small size. • Early Disease Detection– Extreme sensitivity • Ubiquitous Healthcare – Low cost; small size. 3rd World • Global Healthcare – Extremely low cost; small size.

  3. CMOS Magnetic Cell Manipulator

  4. CMOS Magnetic Cell Manipulator CMOS IC CMOS IC + Microfluidics Microcoil array IEEE JSSC (’06); IEEE ISSCC (’05); Lab on a Chip (’07).

  5. CMOS Magnetic Cell Manipulator Magnetic particles BCE Cell IEEE JSSC (’06); IEEE ISSCC (’05); Lab on a Chip (’07).

  6. CMOS NMR Biomolecular Sensor

  7. NMR-Based Biomolecular Sensing(Ralph Weissleder, Harvard Medical School, Nature Biotech 2002)

  8. Commercial Benchtop NMR System Our CMOS NMR System – 1st Genenation 120 kg 2 kg IEEE JSSC (’09); IEEE ISSCC (’08).

  9. Nan Sun

  10. Our CMOS NMR System – 2nd Genenation Silicon RF chip “1-Chip NMR Biosensor” Magnet IEEE ISSCC (’10), IEEE JSSC (’11).

  11. Our CMOS NMR System – 3rd Genenation “Palm NMR Biosensor” Magnet Silicon RF chip 0.1 kg Coil inside 1200x lighter, 1100x smaller, 150x more sensitive IEEE ISSCC (’10), IEEE JSSC (’11).

  12. Proton NMR Measurement IEEE ISSCC (’10), IEEE JSSC (’11).

  13. Biosensing Experiments– hCG (Cancer Marker) Detection – IEEE ISSCC (’10), IEEE JSSC (’11).

  14. Biosensing Experiments Avidin Streptavidin Immunoglobulin Glucose DNA CD 326 Her2/Neu EGFR VEGF CA125 AFP hCG Folic acid S. Aureus Macrophage (RAW 264.7) Partly in Nature Medicine (’08)

  15. Biosensing Experiments– Cancer Detection – Nature Medicine (’08)

  16. CMOS NMR RF Biosensor Smallest NMR CMOS RF + Diagnostics Biosensor: sensitive, rapid, simple, cheap, & hand-held Donhee Ham Research Group

  17. Field-Effect Biomolecular Sensor Solid-State Electronics + Electrochemistry

  18. Field-Effect CMOS Biosensor Microarray

  19. Conclusion All Electronic Bio-analytical Methods Using Silicon CMOS Integrated Circuits Small, Low-Cost  “Enhance our science, life, and economy”

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