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Thymus and Spleen

Thymus and Spleen. The Spleen: What is it good for?. Filters blood Iron Retrieval RBC reserve Immune Response* Fetal Hematopoiesis. The ‘White’ Pulp. Appears basophilic on H&E and red on silver stain Site where immune response is mounted; formation of germinal centers

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Thymus and Spleen

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  1. Thymus and Spleen

  2. The Spleen: What is it good for? • Filters blood • Iron Retrieval • RBC reserve • Immune Response* • Fetal Hematopoiesis

  3. The ‘White’ Pulp • Appears basophilic on H&E and red on silver stain • Site where immune response is mounted; formation of germinal centers • Germinal centers with B cells and B cell derivatives push the ‘central artery’ off to the side

  4. White Pulp Vasculature • The central artery is found in the white pulp • The central artery is surrounded by the PALS, which is T cells • Penicilli branch from the central artery into the red pulp

  5. White Pulp Vasculature • The central artery is found in the white pulp • The central artery is surrounded by the PALS, which is T cells • Penicilli branch from the central artery into the red pulp

  6. White Pulp Vasculature • The central artery is found in the white pulp • The central artery is surrounded by the PALS, which is T cells • Penicilli branch from the central artery into the red pulp

  7. Red Pulp Vasculature: • Penicilli give rise to ellipsoids • Ellipsoids are capillaries ensheathed by reticular cells and macrophages; their lumens are often occluded in histo sections • Blood is filtered by macrophages through fenestrations in the sinusoids

  8. Sinusoids See how the basal lamina is interrupted; evident with both stains

  9. Sinusoids Lining of endothelial cells: apposed to one another, but remain separated Macrophages extend their processes into the lumen of the sinusoid (you can see the remains of RBCs in macrophages)

  10. The Red Pulp • Appears Red on H&E • Composed of sinusoids and Cords of Billroth • The cords are the parenchyma of the red pulp; they are composed of reticular tissue w/ macrophages, red blood cells, and lymphocytes

  11. Silver Stain *Notice how reticular fibers are evident with silver stain and not H&E *Notice the difference in appearance with the two different stains

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