Research in the emory university school of medicine october 28 2010
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RESEARCH in the Emory University School of Medicine October 28, 2010. Carolyn C. Meltzer, MD, FACR William P. Timmie Professor and Chair Associate Dean for Research and Ray Dingledine , PhD Professor and Chair of Pharmacology Executive Associate Dean for Research.

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RESEARCH in the Emory University School of Medicine October 28, 2010

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Research in the emory university school of medicine october 28 2010

RESEARCH in the Emory University School of Medicine October 28, 2010

Carolyn C. Meltzer, MD, FACR

William P. Timmie Professor and Chair

Associate Dean for Research

and

Ray Dingledine, PhD

Professor and Chair of Pharmacology

Executive Associate Dean for Research


Over the next 20 minutes

  • Overview SOM Research Office

  • Research Resources and How to Find Them

  • Plans, Strategies, Challenges and Opportunities for Biomedical Research at Emory

Over the Next 20 Minutes…


Research in the emory university school of medicine october 28 2010

Research at Emory


Research in the emory university school of medicine october 28 2010

School of Medicine

Office of Research and Strategic Initiatives

Ray Dingledine

Exec Assoc Dean for Research

Jeff Lennox

Assoc Dean for

Clinical Research

Carolyn Meltzer

Assoc Dean for Enabling Technologies

Patricia Haugaard

Assistant Dean for Research Admin

Mary DeLong

Assistant Dean for Postdoctoral Educatiom

Mike Huerkamp

Director of Animal Resources

Chuck Elliott

Director,

SOM IT

Kelly Shaw

Project Coord. & AA support

  • SOM Cores:

  • Integrated EM

  • Flow cytometry

  • Transgenic mouse & gene targeting

  • Proteomics

  • Center for Systems Imaging

  • Bimcore

Darryl Barr

Associate Director

Research Admin

Sherie West

Financial Analyst

Michael Hart

Assoc Chief of Staff for VAMC Research


Research in the emory university school of medicine october 28 2010

Functions of the SOM Office of Research

and Strategic Initiatives

  • Oversight of reporting units

    • Department of Animal Resources

    • Clinical Research Office (shared)

    • SOM IT

    • Post doc office

  • Management of research cores*

  • Policies and administrative support for

    • Research space management

    • Large grants, bridge funding, foundation award nominations

    • Compliance

  • Research Strategic Planning


Nih funding emory som 1996 2010

NIH Funding Emory SOM 1996-2010

Annual growth of 11.7% over a 14 year period

NIH Ranking 3130242423232321 23 19 19 181815 16(proj.)

Source: NIH; *preliminary data; grants only


Research in the emory university school of medicine october 28 2010

Alternative growth trajectories

NIH grew 6.4% between

2003 and 2008


Som research strategic plan co chairs dingledine meltzer

SOM Research Strategic Plan(co-chairs: Dingledine/Meltzer)

Build on Research Mission to:

CREATE innovative, collaborative discovery programs that

ADVANCEhealth by prevention, early detection and treatment, and

INSPIRE progress through medical research.

2009 Vision

By 2015, Emory University School of Medicine will have had substantial impact on the understanding of human disease and enhancement of human health, and will be recognized as one of the top 10-15 research-intensive medical schools in the country.


Som research strategic plan co chairs dingledine meltzer1

SOM Research Strategic Plan(co-chairs: Dingledine/Meltzer)

  • Emphasis on

    • Partnerships – e.g. Georgia Tech, CDC, EHC

    • Infrastructure – decrease barriers

    • Achievement – “Mindshare”, Celebrate Gamechangers


Research in the emory university school of medicine october 28 2010

Strategic approaches to vision

Vision

Enhance knowledge,

Improve health

2009

Achievement, Infrastructure, Partnerships

Team Science

Top 10 in

NIH awards

2003

Build Critical Mass

Top 10 in

NIH awards

1997


Research in the emory university school of medicine october 28 2010

SOM Research Plan Strategic Initiatives

  • 1. Culture: Recognize Discovery & Achievement

    • Foster cultural shift from exclusive reliance on financial metrics to including identification of specific research achievements

  • 2. Research Infrastructure

    • Invest in growth and and integration of infrastructure:

    • Regulatory consolidation and administrative process improvement

    • Integration of IS systems in support of research

    • Sustainable core facilities

    • New research space needs

  • 3. Partnerships & Programmatic Growth

    • - Align and integrate clinical and research activities

      • - Further leverage unique partnerships to produce sustained competitive advantage in key areas

  • - Strengthen platform/enabling technologies


  • Som research strategic plan

    SOM Research Strategic Plan

    • Strengthen research core facilities

  • Provide both developing technologies and research service functions within core facilities

  • Implement sustainability planning in order to keep established cores innovative and competitive

  • Consider core models that provide access beyond the SOM (eg, university, regional or national consortia)

  • Provide incentives for the creation of successful value-added cores

  • Provide support for core-dependent grant applications


  • Comparing apples to apples or when is a core a service center

    Comparing Apples to Apples:(or….When is a “Core” a Service Center?)

    • NIH Definitions:

      • Core

        • Shared piece of equipment or facility

        • No fees charged

      • Service Center

        • Shared equipment or facility for which fees are charged to support the cost of running the equipment or facility

        • Service Centers are subject to federal regulations (OMB circular A21) if any fees are paid from a federal grant or contract

    Most of the time when we use the term “core labs”, we are actually are referring to service centers


    Som core lab facilities

    SOM Core Lab Facilities

    • Substantial revisions of the SOM Core Labs past 4 yrs

      • Many older facilities phased out depending on user base, revenue trends

      • More shared facilities

    • A 2006 SOM Research Core Resource Task Force:

      • Complementary constructs:

        • Service Cores

        • Emerging Technologies

      • Strengthened annual progress review process

      • Long term financial/strategic planning

      • RFA for new pilot cores (not implemented)


    Current som core lab facilities

    Current SOM Core Lab Facilities

    • SOM Cores

      • BIM Core

      • BITC

      • Flow Cytometry

      • Behavioral Core

      • Genomics Core

    • Affiliate SOM Cores (i.e., Shared support)

      • Transgenic Mouse Core (WCI)

      • Proteomics Core (Neurology)

      • Center for Systems Imaging (Radiology, WHSC, EU)

      • Robert Apkarian Electron Microscopy Facility (College)


    Do we really have only a handful of cores available to som faculty

    Do We Really Have Only a Handful of Cores Available to SOM Faculty?


    Purpose of the ctsas

    Purpose of the CTSAs

    U54 Consortium designed to transform how clinical and translational research is conducted, ultimately speeding bench-to-bedside translation of discoveries by:

    • Encouraging the development of new methods and approaches to clinical and translational research

    • Improving the training and mentoring to ensure that new investigators can navigate the increasingly complex research system

    • Designing new and improved clinical research informatics tools

    • Assembling interdisciplinary teams that cover the complete spectrum of medical research

    • Forging new partnerships with private and public health care organization


    Goals of the actsi

    Goals of the ACTSI

    • Support cross-cutting scientific discovery, innovative initiatives, and their translation to humans through novel and emerging technologies

    • Establish a culture of community engagement and communication in clinical and translational research

    • Build upon, enhance, and expand successful education programs, clinical research curricula, mentoring, training, and career development


    Research in the emory university school of medicine october 28 2010

    Interdisciplinary Programs

    and Strategic Themes of Atlanta-CTSI

    Emerging Technologies

    NANOTECHNOLOGY

    And

    DRUG DISCOVERY

    INFLAMMATION

    And Vaccines

    Animal Models and

    Imaging

    ACTSI

    PREDICTIVE

    HEALTH

    COMPUTATIONAL

    Life Sciences

    Health

    Disparities

    Regeneration

    and Repair


    Actsi s translational technologies and resources ttr program

    ACTSI’s Translational Technologies and Resources (TTR)) Program

    Enhance existing core capabilities

    Bridge funding (Coulter-like program in development)

    Proof-of-Principle Fund

    Rapid identification/acquisition of new technologies

    Support biomedical symposia

    Disseminate resource information

    Bridging technologies to translation

    Resource Web Portal

    Educational Programming

    Facilitate access to resources

    Provide training opportunities

    Access/Networks/Knowledge

    Dissemination

    Foster collaborations

    Support methods validation / development

    Pilot Studies Fund


    Ttr proof of principle fund

    TTR Proof-of Principle Fund

    • Georgia Research Alliance (GRA) Funds

    • Internal (Emory) Matching Funds

    • $200K per year

    • Proposed investments:

    • Biostatistics Core

    • New service core facilities

    • Sustainability for existing cores

    • “Valley of Death” funding

    • Coulter-like program (in development)

    • $500K per year

    • Annual RFA process

    • TTR Internal Advisory Committees reviews applications and makes recommendation


    Ttr proof of principle fund1

    TTR Proof-of Principle Fund

    New Technology Investments To Date:

    • Deltavisiondeconvolution microscope

    • Next-generation sequencing core capabilities

    • Laboratory Information Management System (LIMS) hardware and software

    • Enhanced proteomics capabilities at Morehouse School of Medicine

    • Multispectral in vivo fluorescence imaging system for small animals

    • RainDance 1000 microdroplet generator (for multiplex PCR)

    • Carl Zeiss PALM System (for super-resolution molecular imaging)

    • Autoloader and fluidics station to upgrade the Affymetrics platform

    • Magnetic resonance spectroscopic (MRS) data analysis software


    Research in the emory university school of medicine october 28 2010

    Imaging

    Animal models of humandisease

    Nanotechnology

    Drug Discovery and High-throughput technologies

    Genomics

    Immunology/ Vaccine

    ACTSI Translational Technology Program

    Focus Areas aligned with ACTSI themes


    A unique technology

    April 8, 2010

    Featured Speaker

    Bernd Pichler, PhD

    Department of Radiology

    University of Tübingen

    A Unique Technology

    • MR/PET symposium a success!


    Emory s approach to the access barrier

    Emory’s Approach to the “Access Barrier”

    • Core Newsletter

    • SOM and ACTSI Websites

    • eBIRT

      • electronic Biomedical Interactive Resource Tool

      • development supported through ACTSI

      • platform for context-based searching of research-related services and content to connect researchers to people and resources


    Biomedical interactive resource tool ebirt

    Facilitating Discovery

    Biomedical Interactive Resource Tool (eBIRT)

    • First release version launched March 12th, 2010

      • Includes lab services, equipment, material, software, training, and other resource types

      • 650+ unique visitors since March 2010 launch

    • Currently 54 core resources from across ACTSI institutions (and growing)

    • Roadmap for version 2 is under development

    • http://ebirt.emory.edu


    Research in the emory university school of medicine october 28 2010

    Henry M. Blumberg, MD, Program Director

    • Master of Science in Clinical Research Program

      • CORE COURSES

        • Introduction to Clinical and Translational Research

        • Analytic Methods for Clinical and Translational Research I and II

        • Biostatistics

        • Data Management

        • Community Engagement/Health Disparities in Clinical Research

        • Clinical Trial Design and Analysis

        • Scientific and Grant Writing for Clinical and Translational Research

        • Fundamentals of Bioinformatics

        • Clinical Research Colloquium

        • Analysis of Clinical Research Data

        • Ethical, Legal, and Social Issues of Responsible Clinical Research

        • Rotation in the Clinical Interaction Network (CIN)

        • Rotation on the Institutional Review Board (IRB)

      • Electives include Behavioral Science and Health Education, Bioinformatics, Biostatistics, Epidemiology, Health Policy and Management, and Biology and Biological Sciences


    Nih grant mechanisms

    NIH Grant Mechanisms

    • Career Development Awards (K-Series)

    • Research Grants (R-Series)

    • Research Training and Fellowships (T & F Series)

    • Program Project and Center Grants (P-Series)

    • Cooperative Agreements (U-Series)


    Research in the emory university school of medicine october 28 2010

    Ethical Conduct of Research by Faculty

    • Authorship

    • Mentorship

    • Conflict of Interest

      • Disclosure vs reporting

    • Medical Professionalism

    • Informed Consent

    Resource through ACTSI website: http://www.atlantactsi.org/

    “Ethical Dilemma of the Week”


    Research in the emory university school of medicine october 28 2010

    Team Science Support through SOM

    • Up to $10K Team Science Support (“butt kicker”)

    • Bridge funding

    • Matching funds - individually assessed


    Research in the emory university school of medicine october 28 2010

    Areas of Research Strength at Emory

    • Neurosciences

    • Vaccine – immunology – infectious disease

    • Cardiology

    • Transplantation – regenerative medicine

    • Rising quickly

    • Cancer

    • Drug discovery

    • Inflammation

    • Genetics

    • Informatics

    • Imaging


    Research in the emory university school of medicine october 28 2010

    Research Resources

    • Clinical Research Office (Jeff Sands, Carlton Dampier, Robin Ginn)

    • CTSA (David Stephens)

    • Assistance with grant applications (Trish Haugaard)

    • Research core facilities (Carolyn Meltzer) (http://corelabs.emory.edu/)

    • Proteomics

    • Genomics

    • BIMCORE

    • Flow cytometry

    • Electron Microscopy

    • Center for Systems Imaging (MRI, PET)

    • Transgenic mouse

    • (29 other departmental or shared cores)

    • General information http://www.med.emory.edu/home/research/ora/index.html


    Looking ahead

    Looking Ahead….


    Summary

    Summary


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