Venous Stasis Ulcers. PathophysiologyVenous ulcers result from damage to the valves in veins of the leg.This leads to increased venous pressureVenous hypertension, circulatory stasis and shear trauma in most superficial skin layers. Venous Stasis Ulcers. PathophysiologyThis stasis triggers an inflammatory reaction mediated by PMN'sRelease of cytokines, oxygen radicals and proteolytic enzymes results in fibrosclerotic remodelling of the skin and then ulceration.Swollen, edematous skin is p30341
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