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Perceived Cognitive Changes During Breast Cancer Chemotherapy

Perceived Cognitive Changes During Breast Cancer Chemotherapy. Linda Piacentine, PhD, ACNP Jiannan Zhang, BSN, RN Alan Bloom, PhD Judith F. Miller, PhD, RN, FAAN. Chemobrain. Cognitive deficits associated with chemotherapy Reported by 15-50%

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Perceived Cognitive Changes During Breast Cancer Chemotherapy

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  1. Perceived Cognitive Changes During Breast Cancer Chemotherapy Linda Piacentine, PhD, ACNP JiannanZhang, BSN, RN Alan Bloom, PhD Judith F. Miller, PhD, RN, FAAN

  2. Chemobrain • Cognitive deficits associated with chemotherapy • Reported by 15-50% • unknown severity and duration of decreased cognition • Cause of the phenomenon not understood • Most common • Verbal and visual memory • Attention/concentration • Processing speed

  3. Study Aim To compare perceived cognitive ability (concentration/attention, fatigue, memory and language/word finding) among women who receive chemotherapy following surgery for breast cancer and healthy women

  4. Study Design/Methods Descriptive, longitudinal Four self-report instruments, administered prior to and after 4 cycles of chemotherapy Data analysis Descriptive analysis of demographics Repeated Measures Anova

  5. Instruments Functional Assessment of Cancer Therapy Cognitive Version (FACT-Cog) 50 items General well-being with Breast Module (FACT-B) 23 items Fatigue (FACIT-F) 13 items Beck Depression Inventory (BDI-II) 21 items

  6. Sample Description • 11 women starting on chemotherapy • No metastasis • No previous chemo • No psych disorders or history of substance abuse • No previous traumatic brain injury • 7 healthy women matched for age and education

  7. Sample Description

  8. Chemotherapy Regimen

  9. Results FACT-Cog & Indicates chemo group n=10 # indicates healthy group n=6 * Indicates a within group change over time Shading indicates a group difference at a specific time point

  10. ResultsFACT-B & Indicates number of participants in chemo group is 10 * Indicates a within group change over time Shading indicates a group difference at a specific time point

  11. ResultsFACIT-F * Indicates a within group change over time Shading indicates a between group difference at a specific time point

  12. ResultsBDI-II

  13. Pre-chemotherapy compared to after 4 cycles: Cognitive impairment increases Physical well-being decreases Fatigue symptoms increase Healthy persons report less fatigue at both timepoints Healthy persons report less cognitive impairment compared to those who have had 4 cycles of chemotherapy Conclusions

  14. Pilot study with small sample size Lack of control group with cancer but no chemotherapy Unable to assess prior to cancer diagnosis and surgery Highly educated women Incomplete data Cognitive tool in development Limitations

  15. Future Directions Compare data to imaging and qualitative data Larger sample size Cancer control group Supported in part by DOD grant BC086890, State of Wisconsin Breast Cancer Check-off Funds and Greater Milwaukee Foundation and MCW Cancer Center

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