Weeks of MCD-fed

1. ** ** ** ** ** ** ** ** Weeks of MCD-fed Supplementary fig. 1. Enhanced specific uptake of [18F]FEDAC in the NAFLD livers versus those of controls (n = 6, respectively). The liver sections were incubated with [18F]FEDAC (0.37 MBq/L)and quantified by in vitro autoradiography. To confirm the specific binding of [18F]FEDAC to TSPO, the sequential liver sections were co-incubated with unlabelledPK11195 (10 mM) and [18F]FEDAC (0.37 MBq/L). **P <0.01

2. Control MCD 2W MCD 4 W MCD 4 W+PK11195 MCD 8W Supplementary fig. 2. Coronal images of the MCD-fed and control mice in figure 1. Positioning of acquired PET/CT transverse images is marked with red line on the CT images.