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Problem Set 1.22.2010 Jimmie Weaver

Problem Set 1.22.2010 Jimmie Weaver. Workshop on Retrosynthesis. Most of the material was commandeered from Corey’s “The Logic of Chemical Synthesis”. Information regarding order of events is contained in the target molecule, (TGT) that is not as obvious in the components.

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Problem Set 1.22.2010 Jimmie Weaver

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  1. Problem Set 1.22.2010 Jimmie Weaver Workshop on Retrosynthesis Most of the material was commandeered from Corey’s “The Logic of Chemical Synthesis”

  2. Information regarding order of events is contained in the target molecule, (TGT) that is not as obvious in the components.

  3. The assembled engine has information that the disassembled one does not, specifically the order of events Recognizing patterns is key to disconnecting the TGT molecule.

  4. Recognizing patterns is key to disconnecting the TGT molecule.

  5. Diels-Alder retrons. Provide the transform products.

  6. Diels-Alder retrons. Provide the transform products.

  7. Diels-Alder retrons. Provide the transform products.

  8. Provide the products of this transform.

  9. Provide the products of this transform.

  10. Provide the products of this transform.

  11. Provide the products of this transform.

  12. Other patterns to identify

  13. Transforms and connection patterns to identify

  14. Transforms and connection patterns to identify

  15. 3,3-rearrangments-synthon

  16. Problem

  17. Problem

  18. Problem

  19. Problem

  20. Problem

  21. Another Problem Hint: Don’t Panic! Just Rearrange It.

  22. Another Problem Hint: Don’t Panic! Just Rearrange It.

  23. Another Problem Hint: Don’t Panic! Just Rearrange It.

  24. Another Problem Hint: Don’t Panic! Just Rearrange It.

  25. Another Problem Hint: Don’t Panic! Just Rearrange It.

  26. Another Problem Hint: Don’t Panic! Just Rearrange It.

  27. Another Problem Hint: Don’t Panic! Just Rearrange It.

  28. Another Problem Hint: Don’t Panic! Just Rearrange It.

  29. Another Problem Hint: Don’t Panic! Just Rearrange It.

  30. Another Problem Hint: Don’t Panic! Just Rearrange It.

  31. Another Problem Hint: Don’t Panic! Just Rearrange It.

  32. Another Problem Hint: Don’t Panic! Just Rearrange It.

  33. Disconnections: Try to remove appendages to rings.

  34. Disconnections

  35. Disconnections

  36. Disconnections

  37. Problem. Hint: when disconnecting, consider the acylic form.

  38. Problem. Hint: when disconnecting, consider the acylic form.

  39. Problem. Hint: when disconnecting, consider the acylic form.

  40. Problem. Hint: when disconnecting, consider the acylic form.

  41. Problem. Hint: when disconnecting, consider the acylic form.

  42. Suggest a retrosynthesis

  43. Suggest a retrosynthesis

  44. Suggest a retrosynthesis

  45. Suggest a retrosynthesis

  46. Suggest a retrosynthesis

  47. Suggest a retrosynthesis

  48. Suggest a retrosynthesis

  49. Suggest a retrosynthesis

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