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Biol 568 Advanced Topics in Molecular Genetics

Ch. 23 Controlling Chromatin Structure. Chromatin remodeling and activationRemodeling complexesTxn factorsHistone ModificationsDNA methylationActive and inactive chromatin. Control of gene expression. Activation of chromatin structureInitiation of txnTxn processingTransport to cytoplasm

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Biol 568 Advanced Topics in Molecular Genetics

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    1. Biol 568 Advanced Topics in Molecular Genetics

    2. Ch. 23 Controlling Chromatin Structure

    3. Chromatin remodeling and activation Remodeling complexes Txn factors Histone Modifications DNA methylation Active and inactive chromatin

    4. Control of gene expression Activation of chromatin structure Initiation of txn Txn processing Transport to cytoplasm Translation

    5. Gene expression analyses Three test systems: Oocyte system Transfection systems Transgenic systems

    6. Chromatin can have alternative states Local chromatin Important part for gene expression: The gene is in an active state only in the cells in which is expressed Epigenetic patterns of gene expression Heterochromatin formation

    7. Activation of Txn In prokaryotes: Requires activator/ repressor Increase of activator/repressor concentration affects txn Equilibrium model

    8. Equilibrium model Fig. 23.1

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