Opportunities for Research Collaboration Calibration and Standardization Seminar December 19, 2008

1. Opportunities for Research CollaborationCalibration and Standardization SeminarDecember 19, 2008 William Brantley (PhD) Professor, Division of Restorative and Prosthetic Dentistry Director, Graduate Program in Dental Materials Science

2. Background

3. Graduate Program in Dental Materials Science Research-oriented with no clinical treatment of patients MS Program is in Division of Restorative and Prosthetic Dentistry with PhD in Oral Biology (Biomaterials Track) Broad curriculum in modern dental materials science Program objective is training of future dental materials science faculty and people who desire industry R & D careers in dental materials and other biomaterials Four stipended positions have historically been available for qualified applicants ― all currently filled Dentists and non-dentists (engineering and chemistry backgrounds) have been accepted into program

4. Graduate Program FacultyResearch Focus Areas William Brantley (PhD) ― Alloys and general dental materials science Isabelle Denry (DDS, PhD) ― New ceramics and characterization of ceramics William Johnston (PhD) ― Color science and general dental materials science Scott Schricker (PhD) ― Polymeric materials and tissue engineering

5. Dental Materials Science ProgramMS Degree Two-year duration if only MS degree desired Combined with PhD program for PhD candidates International PhD students first admitted to MS Program Learn OSU academic style and writing in English

6. Curriculum for MS Program Four Major Dent 700.08 Core Courses – Sequential in Alternate Years Impression Materials, Gypsum Products and Investments (Johnston) Alloys (Brantley) Prosthetic Polymers and Related Materials (Schricker) Ceramics (Denry) Other Major Courses Dent 800 Statistical Inferences and Applications to Dentistry (Rashid) Dent 802 Introduction to Dental Research Designs (Johnston) BME 631 Fundamentals of Biomaterials Dent 999 Research (MS Thesis Project) Additional Courses – Depend on advisor and research focus – Areas recommended are materials science and engineering, chemistry, BME, statistics, and other Dent 700.08 courses (amalgams, composite resins, implant science, and mechanical behavior of dental materials)

7. Oral Biology PhD Program (Biomaterials Track) Dent 884 (Current Issues in Oral Biology) – variable topics, with different courses usually offered twice each year (Past examples: neuroscience, microbiology, immunology, biocompatibility of materials, wound healing, apoptosis, bone, and research methods) BME course areas: cell biology/biochemistry, cell/tissue engineering, biological aspects of materials, and nanoscience – selection depends on research focus and advisor (not mandatory) Dent 700.08 courses (see MS Program) and statistics courses Graduate seminar and ethics course Laboratory rotations if needed to select advisor and research topic (not mandatory) Some students may take courses in Department of Materials Science and Engineering (more quantitative and not mandatory) Dent 999 – PhD research project (typically two years – overall time for degree is 4-5 years and little time lost if enroll first as MS student)

8. Research Collaboration

9. Opportunities for Faculty Research Several new graduate students have recently been admitted into the Dental Materials Science Program All of these new students are providing their own support New research projects will be needed for their MS theses Projects can involve faculty collaboration within Division and across Divisions, and thesis committee membership or co-directorship if faculty member wants greater level of involvement (Need to have graduate faculty status) Example of experimental collaboration across Divisions: Brantley and Mendel – Darin Lunt in Orthodontics for impact testing of mouthguard materials

10. Possible Projects and Division Laboratories Effects of manipulation differences on properties of materials (e.g., working time, setting time, dimensional changes, fracture strength, fracture toughness, bond strength, and casting defects) Laboratory measurements comparing products of same type from different manufacturers (e.g., composite resins, impression materials, cements, casting alloys, and implants) ― of particular clinical importance when new products of unknown performance are introduced by manufacturers Restorative Research Laboratory is well-equipped ― specimen preparation areas, mechanical testing machines (Instron and MTS), optical microscope, measuring microscope, apparatus for contact angle measurement, microhardness tester, furnaces, casting area, and wear machine [Seghi](SEM/EDS, x-ray diffraction, and TEM located in MSE – user fees required) Polymer Research Laboratory (Schricker) has apparatus for FTIR and DSC analyses (functional groups and structural transformations) Colorimeters and other apparatus for color science (Johnston)

11. Strategies for Developing Collaborative Projects New graduate students initially observe current investigations and visit College dental laboratories Program faculty meet with new graduate students about their research interests and arrange for collaboration meetings with interested College faculty [Please communicate your interest – clinicians have advantage of seeing needs] Project development requires review of current published literature, planning of initial pilot experiments with power analysis, design of project with control and experimental groups, and decision about mode of statistical analysis Substantial extramural funding is not needed since availability of laboratory equipment, personnel who do not require support, and contribution of materials by manufacturers

12. Key Links PubMed― http://www.ncbi.nlm.nih.gov/pubmed/ Search medical/dental/biomedical literature by author or by subject (Other search engines for engineering journals) OSU Library― http://library.osu.edu/ Go to “Quicklinks”: Online Journal List to access specific journals (Need to log in with username and password) Recent articles in most journals of dental materials interest can be downloaded without going to Health Sciences Library