1 / 52

Structural Assignment and Synthesis of Palau’amine

Structural Assignment and Synthesis of Palau’amine. Toni Rizk. Beauchemin Research Group Department of Chemistry University of Ottawa. 11. 3. 1. 5. 1. Discovered in 1993 by Scheuer et al.

barbra
Download Presentation

Structural Assignment and Synthesis of Palau’amine

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Structural Assignment and Synthesis of Palau’amine Toni Rizk Beauchemin Research Group Department of Chemistry University of Ottawa

  2. 11 3 1 5 1

  3. Discovered in 1993 by Scheuer et al. • Isolated from the marine sponge Stylotellaaurantiumfound in the Yap sea, east of Asia off the coast of the Philippines • Categorized in the bisguandinepyrrole-imidazole alkaloidfamily. • Shows significant antifungal, antitumor, and   immunosuppressive activities

  4. Coupling constant (Hz) Dihedral Angle (°)

  5. Interproton distance (A) H11/17 H11/H18 H12/H17 Black bars: Original (cis) configuration White bars: Revised (trans) configuration Grey bars: Experimental values

  6. Interproton distance (A) H11/17 H11/H18 H12/H17 Black bars: Original (cis) configuration White bars: Revised (trans) configuration Grey bars: Experimental values

More Related