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Emerging Medical Technologies: Next Gen Sequencing

Emerging Medical Technologies: Next Gen Sequencing. Cynthia N Perry, PhD Assistant Academic Dean of Admissions Assistant Professor, Molecular Medicine Department of Medical Education Foster School of Medicine. Genomics and Healthcare. https:// youtu.be /KiQgrK3tge8. Human Genome.

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Emerging Medical Technologies: Next Gen Sequencing

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  1. Emerging Medical Technologies: Next Gen Sequencing Cynthia N Perry, PhD Assistant Academic Dean of Admissions Assistant Professor, Molecular Medicine Department of Medical Education Foster School of Medicine

  2. Genomics and Healthcare https://youtu.be/KiQgrK3tge8

  3. Human Genome • 3 billion bases arrayed in a unique order, • with ~20,000 genes that direct the synthesis of all the proteins • ~1/1,000,000th of the Human Genome • Polymorphisms or SNPs which differ between people • May influence traits • Possible medical importance

  4. History of DNA Sequencing • 1st Generation = Sanger Sequencing • 2 reads (forward & reverse) • 2nd Generation = Next Generation Sequencing • Millions of reads • 3rd Generation = Single Molecule Sequencing

  5. Sanger Sequencing

  6. Sanger Sequencing

  7. From Sanger to Next-Gen Sequencing

  8. Next Generation Sequencing

  9. Applications IN MEDICINE

  10. Applications in Medicine-Infectious diesease • Clinical Test for TB Patient • Take a sputum sample • Begin culture • ID drug susceptibility ID by NGS

  11. Applications in Medicine - Cancer

  12. Applications in Medicine - prenatal care

  13. Broad Applications • Paternity testing • Wildlife conservation • Herbal supplement validation • Ancestral migration patterns • Origins of traditional medicine

  14. Portable Sequencer (MinION) • Pocket-sized, portable device for biological analysis • Up to 512 nanoporechannels • Simple 10-min sample prep available • Real-time analysis for rapid, efficient workflows • Adaptable to direct DNA or RNA sequencing

  15. Portable Sequencer (MinION)

  16. Next Generation Sequencing In the palm of your hand Practical module Miki Wang, Cynthia Perry, and Jorge Cervantes

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