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Balázs G. Madas IRPA13 Young Professionals Prize Candidate

Possible Consequences of Inhomogeneous Suborgan Distribution of Dose and the Linear No-Threshold Dose-Effect Relationship. Balázs G. Madas IRPA13 Young Professionals Prize Candidate Centre for Energy Research, Hungarian Academy of Sciences. Contents.

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Balázs G. Madas IRPA13 Young Professionals Prize Candidate

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  1. Possible Consequences of Inhomogeneous Suborgan Distribution of Dose and the Linear No-Threshold Dose-Effect Relationship Balázs G. Madas IRPA13 Young Professionals Prize Candidate Centre forEnergy Research, HungarianAcademy of Sciences

  2. Contents • Introduction – a non-treatedissueinradiationprotection: thespatial suborgan distribution of dose • Objective – the possible consequences of spatial inhomogeneity of dose • Methods • Results • Conclusions – differences between exposure from radon and other radiation sources

  3. Introduction – a theoreticalquestion • spatial dose distribution within the organs – notconsidered by radiation protection • very different exposure scenarios – the same effective dose and nominal risk

  4. A practicalissue – radon inhalation • radon progeny – inhomogeneous deposition in the lungs • significant issue in radiation protection • contributiontonaturalradiationburden of thepublic • second most importantcause of lungcancer

  5. Objective • Whatconsequenceshavetheinhomogeneousdose-distribution, • ifnominalrisk is linearfunction of absorbeddose? • ifnominalrisk is non-linearfunction of absorbeddose?

  6. Methods

  7. Results • onlyα-exposure • thelinearfunctionindependentonthedose-distribution • the non-linear functions are much closer to the linear one in case of inhomogeneous exposure

  8. Results • an inhomogeneousα- & a homogeneousβ-exposure • thelinearfunctionindependentonthedose-distribution • the non-linear functions are much closer to the linear one in case of inhomogeneous exposure

  9. Conclusions • Spatial distribution of dose cannot be considered, if the relationship between nominal risk and absorbed dose is linear. • If there are any low dose nonlinearity in risk, it is probably less significant in case of inhaled radon progeny, than in case of radiation sources causing homogeneous exposures. • Proved linear relationship in case of radon does not necessarily mean linear relationship in the low dose range in general. • Proved low dose nonlinearity in case of homogeneous exposures does not necesseraly mean nonlinear risk-exposure relationship in case of radon progeny.

  10. Acknowledgments • I wouldliketothank • Imre Balásházy, mysupervisor • Árpád Farkas & István Szőke forthecomputationsregardingthespatialdosedistribution • theRoland Eötvös Physical Society forthetravelsupport • theOrganizersforgivingtheopportunityforthetalk, and forthebursary e-mail: madas.balazs@energia.mta.hu

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