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Placebo + heparin (ACT  300 sec) (n=696). Abciximab 0.25mg/kg bolus + heparin (ACT  300 sec) (n=395). Abciximab 0.25mg/kg bolus / 10 µg/kg infusion + heparin (ACT  300 sec) (n=708). EPIC: Balloon Angioplasty. Primary Endpoint: Death, MI, UTVR at 30 days. 4.5%  ( P <0.004).

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epic balloon angioplasty

Placebo + heparin (ACT  300 sec)(n=696)

Abciximab 0.25mg/kg bolus + heparin (ACT  300 sec)(n=395)

Abciximab 0.25mg/kg bolus / 10 µg/kg infusion + heparin (ACT  300 sec)(n=708)

EPIC: Balloon Angioplasty

Primary Endpoint: Death, MI, UTVR at 30 days

4.5% (P<0.004)

1.4% (P=ns)

%events

12.8%

11.4%

8.3%

The EPIC investigators. N. Engl J Med. 1994; 330: 956-961.

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30 DayDeath/MI3.5% (P=0.015)

6 MonthDeath/MI3.9% (P=0.019)

30 DayTVR3.8% (P=0.003)

6 MonthTVR5.8% (P=0.007)

Placebo + heparin (ACT  300 sec)(n=696)

Abciximab + heparin (ACT  300 sec)(n=708)

22.3%

MajorTIMIBleeding

16.5%

12.8%

9.6%

8.9%

7.8%

6.6%

6.1%

4.0%

1.4%

EPIC Results

%events

The EPIC investigators. N. Engl J Med. 1994; 330: 956-961.

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