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Beginning of the chapter

47. Beginning of the chapter. Lactose intolerance and genetics (Lactose Sensor). SENSORS. LACTOSE SENSOR. Lactose intolerance. GENETICS. Lactose (in)tolerance. Lactose cannot be directly absorbed in the intestine. Glucose. GLU. LACTOSE.

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Beginning of the chapter

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  1. 47 Beginning of the chapter Lactose intolerance and genetics (Lactose Sensor)

  2. SENSORS LACTOSE SENSOR Lactose intolerance

  3. GENETICS Lactose (in)tolerance Lactose cannot be directly absorbed in the intestine Glucose GLU LACTOSE The lactase enzyme breaks down lactose into smaller parts GAL Galactose GLU GAL Lactase gene

  4. GENETICS Lactose (in)tolerance GLU LACTOSE LACTOSE GAL GLU GAL Age++ Lactase gene

  5. GENETICS Lactose (in)tolerance 1 of 6 people: the lactase enzyme is gradually switched off Mild symptoms Moderate symptoms Severe symptoms Lactase enzyme Lactose intolerance 10 20 30 40 50 60 70 Age (years)

  6. GENETICS Lactose (in)tolerance GLU LACTOSE LACTOSE GAL GLU SNP GAL Age++ Lactase gene

  7. GENETICS Lactose (in)tolerance 5 of 6 people: the lactase enzyme is constantly produced 1 of 6 people: the lactose enzyme is gradually switched off Mild symptoms Moderate symptoms Severe symptoms Lactaseenzyme Lactose intolerance 10 20 30 40 50 60 70 Age (years)

  8. GENETICS Lactose (in)tolerance Genetic variation originated in an European

  9. GENETICS Lactose (in)tolerance Shortage of food caused the death of many people

  10. GENETICS Lactose (in)tolerance Milk as an additional food source = survival advantage

  11. GENETICS Lactose (in)tolerance Lactose tolerant Lactose intolerant

  12. GENETICS Lactose (in)tolerance Lactose tolerant Lactose intolerant

  13. LACTOSE SENSOR Various forms of lactose intolerance Primary lactose intolerance 20% of people Occurs with increasing age Secondary lactose intolerance Acquired (non-genetic) Disease / intestinal damage Congenital lactose intolerance Genetic variation in the lactase gene Very rare Occurs in newborns Milk protein allergy 3% of babies Age++ Lactase gene GLU GAL Age++ Lactase gene

  14. LACTOSE SENSOR What is the relationship between age and lactose intolerance? 0 1 5 16 30 50 80 PRIMARY BABY Sensor Congenital LACTOSE SENSOR MILK ALLERGY ALLERGY SENSOR SECONDARY LACTOSE INTOLERANCE Standard lactose intolerance (breath) test

  15. 47 End of the chapter Lactose intolerance and genetics (Lactose Sensor)

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