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Default mode network: Spontaneous fluctuations in fMRI brain. Jaeseung Jeong, Ph.D. Department of Bio and Brain Engineering, KAIST. Blood oxygen level dependent (BOLD) in fMRI.
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Jaeseung Jeong, Ph.D.
Department of Bio and Brain Engineering,
Spontaneous modulation of the BOLD signal which cannot be attributed to the experimental paradigm or any other explicit input or output is also present. Because it has been viewed as \'noise\' in task-response studies, this spontaneous component of the BOLD signal is usually minimized through averagingon slow (<0.1 Hz) fluctuations in the BOLD signal.
Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.
B Biswal, F Z Yetkin, V M Haughton, J S Hydein, Magnetic Resonance in Medicine (1995)
An MRI time course of 512 echo-planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the somatomotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI).
Detection of functional connectivity using temporal correlations in MR images. Michelle Hampson, Bradley S. Peterson, John C. Gore, Human Brain Mapping (2002)
Positive nodes (warm colours) are correlated with seed regions involved in focused attention and working memory (task-positive seeds) and significantly anticorrelated with seed regions that are routinely de-activated during attention-demanding cognitive tasks (task-negative seeds): the intra-parietal sulcus (IPS), frontal eye field (FEF) and middle temporal (MT) area. . Negative nodes (cool colours) are correlated with task-negative seeds and significantly anticorrelated with task-positive seeds. The task-negative seeds are the posterior cingulate/precuneus (PCC), lateral parietal cortex (LP) and medial prefrontal cortex (MPF)
MPFC has been associated with social cognition involving the monitoring of ones own psychological states, and mentalising about the psychological states of others ([Blakemore, 2008], ).
Buckner R et al. J Neurosci 2005
Cortical Hubs overlap anatomy of A-b deposition
Buckner R et al J Neuroscience 2005