Cancer. By: Aujan M., Zach J., Aditya P. Genetic disease that results in uncontrolled growth. Mutation in genetic code results in failure of cell division control. ~90% of time, cancer mutation due to external environmental factors. Cancer due to inherited mutations ~10% of time. Overview.
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By: Aujan M., Zach J., Aditya P.
Deletion or duplication of nucleotides in genetic sequence can lead to mutation.
Cell undergoes cell division before cell is fully mature. Since they divide at a rapid rate, successive cancer cells will be immature and dysfunctional.
Genes that inhibit cell division are proto-oncogenes. These can mutate and become oncogenes.
Base Pair Substitution – replacement of one nucleotide and complimentary base with another complimentary pair.
Adding/Losing Nucleotide Pairs – more harmful than substitutions because mRNA coded in series of triplets. Loss/gain causes entire sequence to shift over, resulting in shift in reading frame.
Benign Neoplasm – mass of cells whose cellular compositions is same as cells of surrounding tissues.