1 / 26

IMMUNITY

IMMUNITY. INNATE (present before birth, “ NATURAL ”) ADAPTIVE (developed by exposure to pathogens, or in a broader sense, antigens). INNATE IMMUNITY. BARRIERS CELLS: LYMPHOCYTES, MACROPHAGES, PLASMA CELLS, NK CELLS CYTOKINES /CHEMOKINES PLASMA PROTEINS : Complement, Coagulation Factors

aspen
Download Presentation

IMMUNITY

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. IMMUNITY • INNATE(present before birth, “NATURAL”) • ADAPTIVE(developed by exposure to pathogens, or in a broader sense, antigens)

  2. INNATE IMMUNITY • BARRIERS • CELLS: LYMPHOCYTES, MACROPHAGES, PLASMA CELLS, NK CELLS • CYTOKINES/CHEMOKINES • PLASMA PROTEINS: Complement, Coagulation Factors • Toll-Like Receptors, TLR’s

  3. ADAPTIVE IMMUNITY • CELLULAR,i.e.,direct cellular reactions to antigens • HUMORAL,i.e., antibodies

  4. CELLS of the IMMUNE SYSTEM • LYMPHOCYTES, T • LYMPHOCYTES, B • PLASMA CELLS (MODIFIED B CELLS) • MACROPHAGES, aka “HISTIOCYTES”, (APCs, i.e., Antigen Presenting Cells) • “DENDRITIC” CELLS (APCs, i.e., Antigen Presenting Cells) • NK (NATURAL KILLER) CELLS

  5. GENERAL SCHEME ofCELLULAR EVENTS • APCs (Macrophages, Dendritic Cells) • T-Cells (Control Everything) • CD4 “REGULATORS” (Helper) • CD8 “EFFECTORS” • B-Cells Plasma Cells AB’s • NK Cells

  6. The immune response Def: • Immune response :It is a specific defense mechanism developing against particular types of irritants to overcome the irritant on subsequent exposure. Hypersensitivity :Is the change in tissue reaction Following re- exposure to antigen

  7. Type III (immune complex reaction) Ag + Ab Immune complex with slight excess of Ag Diffuse through the wall of blood vessels Precipitate on the endothelial lining & outside blood vessels Activation of complement Inflammatory reaction With increase vascular permeability & exudation PNL Release of chemotactic factor Phagocytose complement & immune complex Proteolytic enzymes Tissue destruction.

  8. Types • @ Serum sickness • Oedema of the eye lid • Generalized lymphadenopathy • Urticaria • Fever & bone aches • @ Arthus phenomenon • Repeated skin injection of the antigen (e.g. insulin) tissue necrosis, hge. And ulceration

  9. Systemic immune- complex disease Acute serum sickness

  10. Arthus reaction

  11. Examples 1- Serum sickness 2- Arthus reaction. 3- Poly arteritisnodosa. 4- Post streptococcal GN. 5- SLE.

  12. Serum sickness

More Related