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Immunity. It is the ability of the body to protect itself against foreign agents [I] Natural [II] Acquired immunity immunity. These are foreign agents protein or glycoprotein which produce an immune response e.g bacteria, viruses and foreign cells.

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Presentation Transcript
immunity
Immunity
  • It is the ability of the body to protect itself against foreign agents
  • [I] Natural [II] Acquired
  • immunity immunity
slide2

These are foreign agents protein or glycoprotein

  • which produce an immune response
  • e.g bacteria, viruses and foreign cells.
  • Antigen
  • Haptens

These are substances with low molecular weight (<8000)

as drugs(pencillin) which combine with a protein in the

body and then behaves as a foreign protein and initiates

immune response.

i natural immunity
[I] Natural immunity

(1) Intact skin.

- Engulfing of foreign particles

(2) phagocytes

- Destruction and digestion of engulfed organisms

(3) The presence of

certain chemical structures as Lysozymes

  • 3-Natural Killer Cells
  • 4-Inflammation
  • 5-COMPLEMENT
  • 6-INTERFERONS
ii acquired immunity
[II] Acquired immunity
  • It is of two types

1-Humoral immunity

2-Cell-mediated immunity:

slide5

Memory T-cells

(Thymus)

Cellular immunity

T-lymphocytes

Cytotoxic

T-cell (T8)

Stim. (+)

Inh. (-)

Helper

T-cell (T4)

Supressor

T-cell

Bone marrow lymphocytes precursors

Stimulation

(+)

Inhibition

(-)

Humoral immunity

Plasma cells

B-lymphocytes

(liver-spleen)

Memory B-cells

Cell mediated immunity

IG’s M,A,G,E,D

secondary immune response

The memory T & B cells persist in the body for years and readily converted to effector cells by exposure to the same antigen giving more rapid and greater immune response as in vaccination.

Secondary immune response

non specific killer cells
NK and LAK cells

K cell

Activated macrophages

Eosinophils

Non-specific Killer Cells
natural killer nk cells
also known as large granular lymphocytes (LGL)

kill infected and malignant cells

activated by IL2 and IFN-to become LAK cells

Natural Killer (NK) cells
lymphokine activated killer lak cell

kills malignant cells

kills transformed and malignant cells

Lymphokine Activated Killer (LAK) cell

IFN

IFN

IL2

IL2

k cells
K Cells
  • morphologically undefined
  • have IgG Fc receptor
  • recognize antibody coated targets
  • could be NK cells (IgG), macrophages (IgG), eosinophils (IgE) or other cells (IgG)
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