Selectivity-determining regions. Nonconserved amino acids in the proximity of the PTP active site (yellow) are involved in recognition of peptide substrates and non-peptide PTP inhibitors. SHP specificity region S118. WPD-loop specificity F182. D48. R47. R24.
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Nonconserved amino acids in the proximity of the PTP active site (yellow)
are involved in recognition of peptide substrates and non-peptide PTP inhibitors
SHP specificity region
Second pTyr binding site
The degree of conservation (blue – most conserved, red least conserved) reflects the Ca-regiovariation score
values of 37 aligned human PTP catalytic domains.
http://ptp.cshl.edu & http://science.novonordisk.com/ptp
Andersen et al Mol. Cell. Biol. 2001