Selectivity-determining regions
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Selectivity-determining regions. Nonconserved amino acids in the proximity of the PTP active site (yellow) are involved in recognition of peptide substrates and non-peptide PTP inhibitors. SHP specificity region S118. WPD-loop specificity F182. D48. R47. R24.

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D48

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D48

Selectivity-determining regions

Nonconserved amino acids in the proximity of the PTP active site (yellow)

are involved in recognition of peptide substrates and non-peptide PTP inhibitors

SHP specificity region

S118

WPD-loop specificity

F182

D48

R47

R24

G259

KNRY-loop

specificity

Second pTyr binding site

The degree of conservation (blue – most conserved, red least conserved) reflects the Ca-regiovariation score

values of 37 aligned human PTP catalytic domains.

http://ptp.cshl.edu & http://science.novonordisk.com/ptp

Andersen et al Mol. Cell. Biol. 2001


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