Selectivity-determining regions. Nonconserved amino acids in the proximity of the PTP active site (yellow) are involved in recognition of PTP substrates and non-peptide PTP inhibitors. SHP specificity region S118. WPD-loop specificity F182. D48. R47. R24. G259.
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Nonconserved amino acids in the proximity of the PTP active site (yellow)
are involved in recognition of PTP substrates and non-peptide PTP inhibitors
SHP specificity region
Second pTyr binding site
Areas of conservation (blue – most conserved, red least conserved) represents the Ca-regiovariation score
values of 37 aligned human PTP catalytic domains.
Andersen et al Mol. Cell. Biol. 2001