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Funding for Academic Environment. Presented by: Ronald Braithwaite, Ph.D. Professor Morehouse School of Medicine Departments of Community Health and Preventive Medicine, Family Medicine and Psychiatry April 27, 2011.

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funding for academic environment
Funding for Academic Environment

Presented by:

Ronald Braithwaite, Ph.D.ProfessorMorehouse School of MedicineDepartments of Community Health and Preventive Medicine, Family Medicine and Psychiatry

April 27, 2011

  • Substance Abuse and HIV/AIDS in Latinos: Linking Research with the Community
slide2

CSR

Referral

and Review

“Anatomy” of the Grant Process

Researcher

Idea

Institution

Program Staff

Funding Opportunity

Announcement (FOA)

RFA or PA

Collaborators

Grant Application

(R01, R03, R21,

K01, K08, etc.)

Revision

$

National

Advisory

Council

Program Staff

extramural research
Extramural Research

NIH has 3 major funding instruments to support extramural research:

  • Grant: Investigator decides the research to be designed or developed and the approach.
  • Contract:Government decides the research to fill their perceived need and establishes detailed requirements.
  • Cooperative Agreement:Similar to grants, but awarding Institute/Center (IC) and recipient have substantial involvement in carrying out the project\'s activities.
nih behavioral and social research support in fy 2002
NIMH $ 408.7

NIDA $ 377.3

NICHD $ 250.2

NCI $ 248.6

NIA $ 243.5

NIAAA $ 183.1

NHLBI $ 108.7

NINR $ 98.0

NIDCD $ 87.9

NINDS $ 71.0

NCRR $ 54.5

NEI $ 54.2

NIDDK $ 42.0

NIAID $ 33.9

NIDCR $ 27.5

OD $ 25.3

NIAMS $ 22.1

NHGRI $ 15.7

NCCAM $ 14.4

NIEHS $ 12.5

NIGMS $ 11.3

FIC $ 5.8

NLM $ 1.8

NIBIB $ 1.0

NCMHD $ 0.7

Total $2,399.5

NIH Behavioral and Social Research Support in FY 2002
so what type of grant is right for me
So … What Type of GrantIs Right for Me?

Stage of research career?

- experience and expertise?

Research needs?

- mentors or collaborators?

- size of project?

Talk with staff …

They will help you find the right funding mechanism.

funding mechanisms
Funding Mechanisms

Graduate Student

NRSA F30, F31, R36, T32

Postdoctoral

NRSA F32, T32

Transition

K01, K08, K23, K12, K22, K99/R00

Early Career

R03, R21, R15

Mid-Career

R01, K02, P01, K24

Senior Investigator

K05

nih grant mechanisms
NIH Grant Mechanisms
  • R01 Traditional investigator-initiated grant

< $500K/yr, 3-5 yrs. Need approval if more than $500K for any year of the grant

  • R03 Small Grant

< $100K for 2 yrs

  • R21 (NCI) Exploratory/Developmental Grant

< $275K for 2 yrs

  • R13Conference Grants

amount dependent on score, timeliness, budget, NIH interest

career development awards
Career Development Awards

Career Development Programs (K series)

  • K01 Mentored Research Scientist Development Award
  • K08 Mentored Clinical Scientist Development Award
  • K22 NCI Transition Career Development Award
  • K23 Mentored Patient-Oriented Research Career Development Award

http://grants1.nih.gov/training/careerdevelopmentawards.htm

nci research fellowships and training funding opportunities
NCI Research Fellowships and Training Funding Opportunities

Fellowships (F series)

  • F32 Individual Postdoctoral Fellows
  • F33 Senior Fellows
  • F31 NIH Predoctoral Fellowship Awards for Minority Students

Training (T series)

  • T32Institutional Research Training Grants

http://grants.nih.gov/grants/guide/pa-files/PA-02-109.html

  • Predoctoral Research Training Partnership Award (TU2)

http://deainfo.nci.nih.gov/concepts/TU2concept.htm

http://grants1.nih.gov/training/careerdevelopmentawards.htm

slide10

Components of a Successful

Grant Application – Bottom Line!

  • Strong Idea
  • Strong Science
  • Strong Application
some key considerations
Some key considerations
  • Write a clear and concise abstract
  • Never assume that reviewers “will know what you mean”
  • Tell a coherent and consistent story
  • Write for a multidisciplinary audience
  • Place your project in a larger scientific/public health context
  • Create a cohesive application package
  • Pay attention to grammar and spelling!!
  • Conduct a “mock” review with colleagues
slide12

Before You Start Writing

  • Do your homework!
    • Find the right NIH Institute
    • Review the Institute FOAs
    • Find the right funding mechanism
    • Know the review committee(s)
    • Talk to the Program Officer at the Institute

Except for deciding on a funding mechanism, there’s no requirement that you do any of these!

slide13

Concept Development

  • Questions to continually ask
    • yourself:
      • -- What will be learned?
      • -- Why is this research important?
planning guide for new applications

Months before receipt date

SUBMISSION

PHASE

PLANNING PHASE

WRITING PHASE

8

7

6

5

4

3

2

1

Receipt Date

Assess yourself, your field, and your resources

Meet institutional deadlines

Brainstorm; research your idea; call NIH program staff

Get feedback; edit and proof read

Set up your own review committee; determine human and animal subject requirements

Planning Guide for New Applications
slide15

The SCIENCE

  • Define a fundamental question
  • Transform idea(s) into an exciting story/
  • “a scientific journey”
  • Build confidence and enthusiasm (and
    • sense of importance/relevance of your
    • particular research to the field)
slide16

Writing -- General Comments

  • Investigate a significant issue
    • in science
  • Use clear and concise language
  • Propose a doable project
slide17

Writing -- General Comments (cont)

  • Create interest and build enthusiasm
  • about project
  • Be very concerned about
    • “packaging”
  • Never assume your audience will
    • “know what you mean”
slide18

Title (the “Hook”)

Clear and descriptive

slide19

Abstract (Project Description)

Present the big picture

slide20

Abstract (Project Description)

… the 2nd “Hook” … use it as another important opportunity

If the reviewers aren’t excited after reading the abstract…………….

slide21

The Application

12 pages

… to convince reviewers

*For RO1s, most Ks and some other grant mechanisms

keep abreast of changes

by subscribing to the NIH Guide!

slide22

Key Personnel

Justify thoroughly

slide23

Biographical Sketch

Who AREyou?

Why are YOU the person to do this?

Personal Statement

Maximum of 15

publications

slide24

Consultants/Collaborators

Justify thoroughly

slide25

Duration of Study

Justify thoroughly

slide26

Budget

Do not underbudgetor overbudget

and

Justify!Justify!!Justify!!!

slide27

Specific Aims

Summary of your goals

What will be the IMPACT!

Your best shot! If the reviewers aren’t enthusiastic

by the end of the Specific Aims they’re

seldom won back.

slide28

Research Strategy – 4 sections

  • Significance
  • Innovation
  • Approach
  • Preliminary Studies/Progress Report
slide29

Significance

Why is what you want to do important?

How will what you want to do change the field?

slide30

Innovation

What’s new here?

Are there novel concepts, approaches,

methodologies?

slide31

Approach

  • Provide rationales throughout as to why certain methods were selected and why key alternatives were not
  • Provide timeline – a realistic and well- planned estimate of start/end times for each experiment
  • Address potential problems and solutions
slide32

Approach

  • Exercise humility – it is far better to
  • identify weaknesses and explain how
  • you will deal with them than it is to
  • hope that the reviewers won’t
  • find them (they always do!)
  • Highlight strengths of application
  • whenever you can!
slide33

Approach

(Avoid These Criticisms!)

  • Not enough detail
  • Methods out of date
  • Experiments don’t test the hypotheses
  • What hypothesis/hypotheses?
slide34

Approach

(Avoid These Criticisms!)

  • Fishing expedition
  • No place to go if Aim 1 fails
  • Inappropriate statistical analysis
  • Insufficient power
  • Sequence & priorities missing - logic/flow
slide35

Be ProACTIVE!!!

Be PERSISTENT!!!

PLAN Ahead!!!

And Don’t Forget to talk with

your PROGRAM OFFICER!!!

overall impact
“OVERALL IMPACT”
  • Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following five core review criteria, and additional review criteria (as applicable for the project proposed). 
1 st level review
1st Level Review
  • Standing study section typically has 12-24 members
  • Typically 3 meetings each year face-to-face or electronic
  • Review 60 - 100 applications at each meeting
summary statement
Summary Statement
  • The summary statement contains:
    • Overall Resume and Summary of Review Discussion for applications that are discussed
    • Essentially Unedited Critiques
    • Priority Score and Percentile Ranking, if given
    • Budget Recommendations
    • Information about human subjects and other matters, as needed, and administrative notes
slide40

NOW WHAT TO DO?!

  • Read summary statement
  • Re-read summary statement
  • Talk with your Program Officer
  • Talk with your colleagues
  • If the weaknesses can be fixed, revise and
  • resubmit the application
common problems in applications check prior to submission
Common Problems in Applications(check prior to submission)
  • Diffuse or unfocused research plan
  • Studies lack cohesiveness
  • Insufficient detail
  • Insufficient evidence of knowledge of relevant literature
  • Unrealistically large amount of work
  • Uncertainty concerning future directions
  • Lack of specific data to show feasibility of approach
common problems in applications continued
Common Problems in Applications (Continued)
  • Absence of new or original ideas
  • Absence of an acceptable scientific rationale
  • Insufficient evidence of experience in the essential methodology
  • Outdated methodologies
  • Questionable reasoning in approach
  • Uncritical approach
  • Poor preparation and presentation
common problems in applications continued1
Common Problems in Applications (Continued)
  • Inadequate consideration of protection

for human or animal subjects; absence or

problems with data and safety monitoring

procedures

  • Missing or inadequate inclusion of
        • Women
        • Minorities
        • Children
on time submission
On-Time Submission
  • Initial submission must have a Grants.gov timestamp on or before 5:00 p.m. local timeof submitting organization on the receipt date.
my top ten critical factors
My Top Ten Critical Factors
  • Identify the gap in science you will fill
  • Clearly define Hypothesis/Scientific Aims
  • Clearly define design
  • Clearly define primary outcome
  • Link outcomes to specific measures
  • Limitations Section: proactively defuse weaknesses and justify your decisions
  • Have others read it prior to submission
  • Detailed Recruitment and Retention
  • Timeline/Feasibility
  • Pilot Data, Pilot Data, Pilot Data
  • Repeat core Issues at least 3X
  • Explain your rationale/choices
why points are deducted by me
Why points are deducted (by me)
  • Design
    • Unclear
      • Schedule of assessment
    • Wrong Control Group
  • Lack of Theoretical Grounding
  • Wrong Statistical Model
  • Insufficient/Incorrect Power Calculations
  • Lack of Pilot Data (RO1 only)
  • Weak/Wrong/Unspecified Measures
the top ten list
The “Top Ten” List
  • Read and re-read the program announcement
  • Assemble a strong research team
  • Use the strongest study design possible
  • If you have not been on a study section, confer with someone who has
  • Be sure to document the innovations(s)
  • Document strong access to the study population
  • Make sure the writing, organization, & grammar are as tight as possible (write, re-write…read, re-read)
  • Seek reviews before submission
  • Make careful use of the summary statement
  • Persevere and don’t take rejection personally
most common problems
Most Common Problems
  • Lack of new or original ideas
  • Diffuse, superficial or unfocused research plan
  • Lack of knowledge of published relevant work
  • Lack of experience in the essential methods
  • Uncertainty concerning the future directions
  • Questionable reasoning in methodological approach
  • Absence of an acceptable scientific rationale
  • Unrealistically large amount of work
  • Lack of sufficient methodological detail
  • Uncritical approach
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