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methylation

methylation. O- methylation N- methylation S- methylation For phenolic OH as NA As histamine As 6-mercaptopurine Trnsfer is from S- adenosyl methionine (SAM)

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methylation

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  1. methylation O-methylation N-methylation S-methylation For phenolic OH as NA As histamine As 6-mercaptopurine Trnsfer is from S-adenosylmethionine (SAM) Although it is not an important way for drug metabolism ,it is important in biosynthesis of endogenous compounds as folic acid It is important for inactivation of biogenic amines

  2. SAM is electrophil

  3. Methyl transferase Catechol-O- Phenol-O- Non specific N and S

  4. General remarks on metabolism Effect of drugs on metabolism

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