Transposons. CA García Sepúlveda MD PhD. Laboratorio de Genómica Viral y Humana Facultad de Medicina, Universidad Autónoma de San Luis Potosí. Session #25-26 Transposons Introduction. Genomes evolve both by rearranging existing sequences and by acquiring new sequences.
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CA García Sepúlveda MD PhD
Laboratorio de Genómica Viral y HumanaFacultad de Medicina, Universidad Autónoma de San Luis Potosí
Plasmids move by conjugation.
Extrachromosomal elements move information horizontally by mediating the transfer of short lengths of genetic material.
Phages spread by infection.
Both plasmids and phages occasionally transfer host genes along with their own replicon.
In eukaryotes, some viruses (notably the retroviruses) can transfer genetic information during an infective cycle.
In other cases, the modules are only closely related (Tn10, Tn5).
The stagger between the cuts determines the length of the direct repeats and reflects the geometry of the enzyme involved in cutting target DNA.
The generation and filling of the staggered ends explain the direct repeats of target DNA at the site of insertion.
The use of staggered ends is common to all transposons!
repressor > transposase
repressor < transposase
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The difference in genome size observed betwen the different lifeforms are thought to be the result (in large part) of transposon activity.
One of the world's most distinguished cytogeneticists.First to document many fundamental genetic ideas under the microscope, including genetic recombination by chromosomal crossover during meiosis.Produced the first genetic map for maize.
Demonstrated the role of the telomere & centromere.
Discovered Dissociator & Activator Transposition (~Hybrid dysgenesis in Maize)1983 Nobel laureate in Physiology & Medicine
Barbara McClintock (Jun 16, 1902 – Sept 2, 1992).