Suggested HW Ch. 5. 1 – 9 (Chapter 5.1, 5.2) Note: Protein Explorer (originally due Friday) delayed. K d. What is the definition of K d ?
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Four bind heme nitrogens
One binds protein histidine
One can bind O2
Proximal His coordinates
Distal His binds oxygen
for carbon monoxide
CO still preferred over O2
allows O2 exit &
“Three-over-three a-helical sandwich”
Hemoglobins, myoglobins, cytoglobins, etc
Myoglobin•O2 ↔ Myoglobin + O2
Hyperbolic dependence of O2 binding on pO2
Myoglobin: good at “picking up” O2, but won’t let go