Suggested HW Ch. 5. 1 – 9 (Chapter 5.1, 5.2) Note: Protein Explorer (originally due Friday) delayed. K d. What is the definition of K d ?
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Four bind heme nitrogens
One binds protein histidine
One can bind O2
Proximal His coordinates association with protein
Distal His binds oxygen
for carbon monoxide
CO still preferred over O2
allows O2 exit &
“Three-over-three a-helical sandwich”
Hemoglobins, myoglobins, cytoglobins, etc
Myoglobin•O2 ↔ Myoglobin + O2
Myoglobin: association with protein
Hyperbolic dependence of O2 binding on pO2
Myoglobin: good at “picking up” O association with protein2, but won’t let go