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Development of Urinary system and reproductive system. 1. Development of kidney and ureter 2. Development of urinary bladder and urethra 3. Abnormality in urinary system 4. Development of gonad 5. Development of reproductive tracts 6. Abnormality in reproductive system. 3rd week:

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development of urinary system and reproductive system
Development of Urinary system and reproductive system

1. Development of kidney and ureter

2. Development of urinary bladder and urethra

3. Abnormality in urinary system

4. Development of gonad

5. Development of reproductive tracts

6. Abnormality in reproductive system

slide2

3rd week:

HeadsegmentationNephrotome →

Intermediate Pronephros

Mesoderm

Other migration, proliferation Nephrogenic cord

→ Mesonephros and Metanephros

slide3

Mesonephric ridge

Urinary system,

Genital excurrent ducts

Gonadial ridge

Gonad

Intermediate mesoderm

3rd week

Nephrogenic cord

Urogenital ridge

Intermediate mesoderm

─────→

───→

───

Pudendum

slide4

Mesonephric ridge

Urogenital ridge

Gonadial ridge

slide5

Mesonephric ridge

Gonadial ridge

development of urinary system

Pronephric duct

Pronephric tubule

Development of urinary system

1. Pronephros 4th week

Development of kidney and ureter

Nephrotome (7-14th Somite)

Degeneration in 1 week

Mesonephric

duct

slide7

Pronephric

tubule

Pronephros

Time:4th week

Function:no

Destiny: degeneration

slide8

2. Mesonephros 14-18th somite

Middle part of nephrogenic cord

80 transverse S-shaped tubule

Mesonephric tubule

Mesonephric duct

Continus to pronephric duct

Inner end form renal capsule

Glomerulus

Outer end bind to mesonephric duct

The end bind to cloaca

slide9

Time:

end of 4th week

Function:

transient urinary

Destiny:

Most degeneration,

Small part form male excurrent duct

Mesonephric duct

Mesonephric tubule

slide10

3.Metanephros

  • Time:begin at 5th week,
  • exist forever
  • Function:begin at 3th month,
  • urinary function
  • Position:rise gradually

Metanephros

slide11

End of mesonephric duct

(adjacent to cloaca)

Origin

one

Ureteric bud

Prolong

Ureter

Embranchment >12

Renal pelvis, renal calyce

(The end branched as T)

Collecting tube

slide12

Origin

two

(Mesoderm of the mesonephric ridge)

Metanephrogenic blastema

Cap-shaped cell cluster

S-shaped tubule

Bind to collecting tubule

Renal capsule

Glomerulus

+

Renal tubule

Renal corpuscle

Nephron

slide13

Metanephrogenic blastema

Mesonephric tubule

Collecting tubule

Renal pelvis

Renal calyce

Ureteric bud

slide15

Male

Female

Upper:

Urinary bladder

Urinary bladder

Urogenital sinus

Upper part

of urethra

Urethra

Middle:

4-7th week

Urorectal septum

Lower part

of urethra

Vestibule of vagina

Lower:

Anorectal canal

Development of urinary bladder and urethra

Cloaca

slide17

Positional evolvement of

UreterandMesonephric duct

Ureter

Mesonephric duct

slide18

Abnormality

  • Double ureter
  • Urachal fistula
  • Exstrophy of bladder
  • Polycystic kidney
  • Horseshoe kidney
  • Single kidney
single kidney
Single kidney

Right single kidney

Left single kidney

development of gonad
Development of gonad

Gonad differentiation at 7th week

Developmental stage:

Sex undifferentiated stage→ Sex differentiated stage

Reproductive tracts:2 → 1

Proper current: → Feamle

slide27

Endoderm cells of yolk sac

4th week

Proliferation, differentiation

Primordial germ cells

Migration in one week

6th week

6th week

Gonadial ridge

Primary sex cord

Superficial epithelium →cell cords

1.Development of

undifferentiated gonad

Development of gonad

slide28

Primordial germ cells

Large and round endoderm cells in yolk sac

histocompatibility y antigen
Histocompatibility Y antigen
  • H-Y antigen determine the differentiation to testis

The gene of H-Y antigen located at Y chromosome

The cell membrane of the cell which sex chromosome

is XY possesses H-Y antigen

  • Primary sex cord H-Y antigen proliferation

seminiferous tubule

slide31

Mesenchymal cell

Primordial germ cells

Cells of sex cord

Spermatogonium

Sustantacular cell

Interstitial cell

2. Development of testis

Primary sex cord (H-Y antigen)

7th week

Separated from surface

+

+

Testis

slide32

Secondary sex cord (cortical cord)

16th week

Mesenchymal cells

Primordial follicle

Ovary

Stroma

3. Development of ovary

Superficial epithelium

Primary sex cord

(No H-Y antigen)

After 10th week

Degeneration

Primordial germ cells

Cells of sex cord

+

+

Oogonium

Follicular cells

slide34

Ovary

Testis

Rete testis

Tubule rectus

Follicle

Seminiferous

tubule

Spermatogonium

Primaryoocyte

Sustantacular cell

Follicular cell

Follicle

Seminiferous tubule

slide35

4. Descend of testis

and ovary

Embryo →lengthen

Gubernaculum →shorten

7th to 8th month → Scrotum

slide36

Development of reproductive tracts

1. Undifferentiated stage:

slide37

2. Differentiation of female reproductive tract

End of upper segment:Fimbria

Upper and middle segment:oviduct

Lower segment:Uterus

End:Vaginal fornix

Paramesonephric duct:

Sinus tubercle:

Vaginal plate Vagina

Mesonephric ducts and tubules

Degeneration

slide38

3. Differentiation of male reproductive tract

Head ── Epididymal duct

Tail ── Spermaduct

Metanephric duct

Most of →degeneration

Some of → Efferent ducts

Mespnephric tubules

Paramesonephric duct

Degeneration

slide40

Abnormality of reproductive system

1. Cryptorchidism

2. Congenital inguinal hernia

3. Double uterus

4. Vaginal atresia

5. Hypospadias

6. Hermaphroditism

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