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Results Participants in higher GGT quartiles

HOW ELEVATED GAMMA-GLUTAMYLTRANSFERASE ACTIVITY INFLUENCE CARDIOVASCULAR RISK PROFILE IN PATIENT WITH LIVER STEATOSIS?

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Results Participants in higher GGT quartiles

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  1. HOW ELEVATED GAMMA-GLUTAMYLTRANSFERASE ACTIVITY INFLUENCE CARDIOVASCULAR RISK PROFILE IN PATIENT WITH LIVER STEATOSIS? A. Peltec1*, V. Ivanov2, A. Pereteatco3, V. Dumbrava1, M. Popovici21Department of Internal Medicine Nb 4, University of Medicine and Pharmacy “NicolaeTestemitanu”, 2Clinic of Cardiomyopathy and Myocarditis, Institute of Cardiology, 3CLinic of Cardiology, Central Railways Hospital, Republic of Moldova. *apeltec@yahoo.com Background:  Gama-glutamyltransferase(GGT) is a marker of alcohol intake, but may also reflect oxidative stress and nonalcoholic fatty liver disease. Several recent epidemiological studies have found positive associations of GGT with incident cardiovascular events.  Aim:  To investigate the association of elevated GGT activity with the 10-years risk of cardiovascular events in patients with liver steatosis. Methods: A total of 100 patients (mean age: 48,15 ± 10.5 years, 72% males) who had liver steatosis were included in the study. The 10-years risk of cardiovascular events was calculated according to Framingham equation. The risk score were categorized using predefined cutoffs as intermediate (≤ 20%) and high (> 20%). GGT was divided into age- and sex-dependent quintiles to evaluate the association of GGT with CVD risk factors and clinical covariates including age, sex, systolic and diastolic BP, LDL and HDL cholesterol, serum triglycerides, diabetes, body mass index (BMI), smoking status, and alcohol consumption. We used multiple-adjusted Cox proportional hazards regression models to assess the effect of GGT on CVD risk factors. Results Participants in higher GGT quartiles (all patients had elevated GGT activity more than 75 U/L) were older, had higher BMI, were more likely to have hypertension, diabetes mellitus, heavy alcohol consumption (> 50 ml/day) elevated lipids, liver enzymes (ALAT, ASAT) (p< 0,001) P<0,001 Conclusion:  1. Elevated gamma-glutamyltransferase activity influence cardiovascular risk profile in patient with liver steatosis 2. Measurement of GGT activity may be useful in predicting cardiovascular risk After adjusting for known CVD risk factors, compared with the lowest quintiles (GGT less than 36 U/L), odds ratios (95% confidence intervals) were: third quintiles (GGT 51 - 75 U/L): 3,17 (1,68-10.97) highest quartile (GGT more than 75 U/L): 4.69 (1.16-15.9). THE INTERNATIONAL LIVER CONGRESS 2011 46 th ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER Berlin , Germany, March 30 - April 3, 2011

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