slide1
Download
Skip this Video
Download Presentation
GOUT

Loading in 2 Seconds...

play fullscreen
1 / 14

GOUT - PowerPoint PPT Presentation


  • 346 Views
  • Uploaded on

GOUT. TAHIRA KHAN UG-3B. INTRODUCTION:. GOUT is known as the “disease of kings “ and “rich man’s disease”. Gout  (also known as  podagra  when it involves the big toe )

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' GOUT' - aderes


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

GOUT

TAHIRA KHAN

UG-3B

introduction
INTRODUCTION:
  • GOUT is known as the “disease of kings “ and “rich man’s disease”.
  • Gout (also known as podagra when it involves the big toe)
  • it is a medical condition usually characterized by recurrent attacks of acute inflammatory arthritis-red, tender, hot, swollen joints
  • Gout is a kind of arthritis that occurs when uric acid builds up in blood and causes joint inflammation.
  • Gout effects more men then woman in them occurs after menopause

http://www.jfootankleres.com/content/pdf/1757-1146-4-13.pdf

causes
CAUSES
  • Hyperuricemia is the underlying cause of gout.
  • diet, genetic predisposition, or underexcretion of urate
  • Low uric acid level in blood
  • the exact cause is unknown.
  • Partly genetic cause in the genes  contributing to about 60% of variability in uric acid level
  • ThreegenesSLC2A9, SLC22A12 and ABCG2 have been found to commonly be associated with gout, and variations in them can approximately double the risk
  • Loss of function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia by reducing urate absorption and unopposed urate secretion

www.ncbi.nlm.nih.gov

symptoms
SYMPTOMS
  • gouty arthritis
  • Acute gouty arthritis in big toe(podagra)
  • Kidney stones
  • Acute pain in joints
  • Uric acid crystal depositon in the form of tophi
  • Tophi in ear lobe, achilles ankle and elbow
  • Fatigue
  • Mailase
  • High uric acid levels

http://www.aafp.org/afp/1999/0215/p925.html

types of gout
TYPES OF GOUT
  • Depending upon the symptoms and severity of disease gout is classified into
  • Acute gout
  • Chronic gout
acute gout
ACUTE GOUT
  • Acute gout is a painful condition that typically affects one joint
  • Symptoms usually involve only one or a few joints. The big toe, knee, or ankle joints are most often affected.
  • throbbing, crushing, or excruciating pain
  • joint appears warm and red
  • fever.
  • The attack may go away in a few days, but may return from time to time. Additional attacks often last longer.
  • After a first gouty attack, people will have no symptoms. Half of patients have another attack.

http://www.aafp.org/afp/1999/0215/p925.html

chronic gout
CHRONIC GOUT
  • Those with chronic arthritis symptoms include:
  • joint damage and
  • loss of motion in the joints.
  • joint pain and other symptoms most of the time.
  • Tophi below the skin around joints or in other places. Tophi usually develop only after a patient has had the disease for many years.

http://www.aafp.org/afp/1999/0215/p925.html

diagnostic tests
DIAGNOSTIC TESTS
  • Synovial fluid analyis (shows uric acid crystals)
  • Uric acid – blood
  • BUN (blood urea nitrogen
  • Joint x-rays (may be normal)
  • Synovial biopsy
  • Uric acid – urine
  • Creatninelevel
examination of synovial fluid
EXAMINATION OF SYNOVIAL FLUID
  • ASPIRATION:
  • The health care provider uses a needle attached to a syringe to draw out fluid from the affected joint.
  • LAB ANALYSIS:
  • The fluid sample is sent to a laboratory for analysis. Testing can reveal the presence of monosodium urate (MSU) crystals, which will nearly always confirm a diagnosis of gout. The laboratory can also test the sample for infection.
  • The procedure itself can cause infection, though this occurs in less than 0.1% of patients. Aspiration sometimes eases the patient\'s symptoms by reducing swelling and pressure on the tissue surrounding the joint.

http://www.umm.edu/patiented/articles/what_risk_factors_gout_000093_5.htm#ixzz2BBsc1QLS

treatment
TREATMENT

COLCHICINE

Produces its anti-inflammatory effects by binding to the intracellular protein tubulin, preventing its polymerization leading to the inhibition of leukocyte migration into affected area.

Inhibits the synthesis & release of leukotrienes.

  • NSAID,s
  • Colchicine
  • Uricosuricagents
  • Allopurinol
ad