Threats to the Interpretation of Clinical Trials. Inadequately powered studiesSurrogate markers and short follow-upPoor follow-upAbsence of pre-specified monitoring plans. . In order to carry out a proper intention-to-treat analysis all patients must be followed. Intention-to-treat - an analysis which includes all randomized patients in the groups to which they were randomly assigned, regardless of their compliance with the entry criteria, regardless of the treatment they actually receive1146
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