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Alcohol Metabolism. Break Down and Removal. Small Amounts Unmetabolized (10%). Sweat Urine Breath. 1st Pass Metabolism. Occurs in the Stomach Gender Differences Exist: Men have a > level of ADH than women Early metabolism translates to lower BAC levels . 2nd Pass Metabolism.

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alcohol metabolism

Alcohol Metabolism

Break Down and Removal

1st pass metabolism
1st Pass Metabolism
  • Occurs in the Stomach
  • Gender Differences Exist: Men have a > level of ADH than women
  • Early metabolism translates to lower BAC levels
2nd pass metabolism
2nd Pass Metabolism
  • Occurs in the Liver
  • 1st liver enzyme--Alcohol Dehydrogenase (ADH)-----> Acetaldehyde
  • 2nd liver enzyme--Acetaldehyde Dehydrogenase----> Acetic Acid
  • Acetic Acid oxidized by body organs----> CO2 + H2O
blood alcohol concentration
Blood Alcohol Concentration
  • THE RATIO OF ALCOHOL IN THE BLOOD TO THE TOTAL VOLUME OF BLOOD EXPRESSED AS A PERCENT
  • THE PERSUMPTIVE LEVEL OF INTOXICATION = .10%
  • FOR A 160 LB. INDIVIDUAL EACH DRINK = .02% *note size
problem
PROBLEM
  • If an individual weighing 160 lbs. consumes 2 drinks per hour, what will his/her BAC level be at the end of that time?
solution
SOLUTION

Hour 1: .02 + .02 = .04 - .02 = .02%

Hour 2: .02 + .02 = .04 - .02 + .02 = .04%

Hour 3: .02 + .02 = .04 - .02 + .04 = .06%

Hour 4: .02 + .02 = .04 - .02 + .06 = .08%

Hour 5: .02 + .02 = .04 - .02 + .06 = .10% DUI

alcohol s effect on the body
ALCOHOL’S EFFECT ON THE BODY
  • DIGESTIVE SYSTEM:
    • IRRITANT
    • INCREASING AMOUNTS IMPEDE OR STOP DIGESTION
    • PYLORIC VALVE MAY BE EFFECTED “STUCK”
alcohol s effect on the body1
ALCOHOL’S EFFECT ON THE BODY
  • CIRCULATORY SYSTEM
    • MINOR EFFECTS
    • HEARTBEAT & BLOOD PRESSURE LITTLE EFFECT
    • VASODILATOR OF SURFACE VESSELS
    • BODY HEAT LOSS (HYPOTHERMIA)
alcohol s effect on the body2
ALCOHOL’S EFFECT ON THE BODY
  • KIDNEYS
    • INCREASED URINE OUTPUT
      • CONSUMING LARGE QUANTITIES OF LIQUID
      • REDUCES THE PITUITARY HORMONE ADH (ANTIDIRURETIC HORMONE)
alcohol s effect on the body3
ALCOHOL’S EFFECT ON THE BODY
  • LIVER
    • ELIMINATES LIVER PRODUCTION OF GLUCOSE CREATING HYPOGLYCEMIA
    • BRAIN DEPRIVED OF PROPER NOURISHMENT
    • WEAKNESS, NERVOUSNESS, SWEATY, HEADACHE, TREMORS
    • FATTY LIVER
alcohol s effect on the body4
ALCOHOL’S EFFECT ON THE BODY
  • WHITE BLOOD CELLS
    • ACUTE ALCOHOL CONSUMPTION SUCH AS BINGE DRINKING HAS A DIRECT EFFECT ON:
      • WBC RESERVES
      • CHEMOTAXIS
      • WBC ADHERENCE TO BACTERIA
alcohol s effect on the body5
ALCOHOL’S EFFECT ON THE BODY
  • CENTRAL NERVOUS SYSTEM

1 dk/hr BAC .02 little change

2 dk/hr BAC .05 drinker high, judgement center of brain affected, inhibitions lowered

3 dk/hr BAC .10 judgement is nil, muscle coordination depressed, stagger, slur speech

alcohol s effect on the body6
ALCOHOL’S EFFECT ON THE BODY

10 dk/hr BAC .20 emotions erractic, poor memory

1 pint/hr BAC .25 - .30 stuporus, judgement long gone, coordination wiped out, sensory perception almost gone

1.25 pints/hr BAC .40 coma, brain center which controls heart & lungs partially anesthetized

alcohol s effect on the body7
ALCOHOL’S EFFECT ON THE BODY

.40 - .50 coma

.60 death

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