Download
1 / 14
E N D
Route Of Drug Administration Clinical Pharmacology
1 Entered Route Of Drug Administration It Means To Drug Give By GIT A} Oral Route Of Drug Administration B} Sub Lingual Route Of Drug Administration C} Rectal Route Of Drug Administration
A} Oral Route Of Drug Administration It Means Drug Give By Mouth Advantage • It is in easy method of drug administration • it is does not need antiseptic procedure • It is not risky Method • It is cheap route of drug administration • It is not painful method
Disadvantage This route is not suitable in emergency cases cannot be used in people who are vomiting Cannot be used for unconscious person Some drug aur harmful for stomach e.g aspirin
B} Sub Lingual Route Of Drug Administration Drug Is Kept Under Tongue. Advantage • Rapidly soluble method • Easy method • Cheap method
Disadvantage Most drugs are not available as sublingual formulations. The taste of the sublingual dosage form may not be liked by the patient. Placing the sublingual dosage form under the tongue until it dissolves may be considered inconvenient by some patients. Irritation to the oral mucosa.
C} Rectal Route Of Drug Administration Drug Is Kept In Rectum Advantage • It is an easy method • Drug maybe used in local problem e.g constipation
Disadvantage Mucosal irritation. Patient compliance. Erratic and undesired absorption. Placement too high into rectum may lead to first pass metabolism. Installation may trigger defecation reaction. GI state affects absorption:
2 Parenteral Route Of Drug Administration It Means To Drug Give By Injection Advantage • Can be used for drugs that are poorly absorbed, inactive or ineffective if given orally. The IV route provides immediate onset of action. The intramuscular and subcutaneous routes can be used to achieve slow or delayed onset of action. Patient concordance problems can be avoided. • • •
Disadvantage Drug administration by these routes is irreversible and poses more risks than the other routes. It is an invasive route of drug administration and thus, it can cause fear, pain, tissue damage, and/or infections.
3 Inhalation Route Of Drug Administration It Means To Drug Give By Through Lungs Advantage • It is possible to administer larger doses than this. • Modifying the dose of the drug, according to the needs of the patient is simple. • Inhalation therapy facilitates self-administration and therefore increases the compliance of patients. • It is possible to formulate a combination of different types of drugs in a single dose for the treatment of disease.
Disadvantage The major disadvantage of the inhalation route of drug administration is that limited drugs are suitable for formulation with this technique. Cleaning after each application is necessary to avoid potential contamination. The active pharmaceutical ingredients (API) and excipients those have an unpleasant taste and odor are difficult to formulate.
4 Topical Route Of Drug Administration It Means To Apply Drugs On Target Part Advantage • Fewer Risks of Gastrointestinal Difficulties. Different individuals absorb medication at different rates. ... • Fewer Risks of Abuse. ... • Easy to Administer. ... • Reduced Hospital Congestion
Disadvantage Potential production of irritant and allergic contact dermatitis. Decreased penetration in the affected area. Potential rapid appearance of bacterial resistance. Potential alteration of cutaneous flora.
