Langerhans Cell Histiocytosis. I2 王鐘慶. Introduction. Accumulation and infiltration of monocytes, macrophages, and dendritic cells in the affected tissues. Classification of Histiocytosis Syndromes in Children. Classification of Histiocytosis.
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H&E (left) demonstrates characteristic giant cells (large arrow), eosinophil infiltrate (eosinophil demonstrated between two small arrows), as well as lymphocytes (single small arrow). Positive CD1a immunohistochemistry (right) demonstrates characteristic membranous staining.
EM demonstrating ultrastructural Birbeck granules (cluster between two arrows).