Animal Welfare Training
Download
1 / 11

Animal Welfare Training The Development Process - PowerPoint PPT Presentation


  • 279 Views
  • Updated On :

Animal Welfare Training. The Development Process. Remember This!. Computer Models Chemical Models In-Vitro Models In-Vivo Models Human Models. The Drug Development Process. Is it safe? Does it work?. Compound X. How much? How often? How should it be put

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Animal Welfare Training The Development Process' - RoyLauris


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

The development process l.jpg
The Development Process

Remember This!

  • Computer Models

  • Chemical Models

  • In-Vitro Models

  • In-Vivo Models

  • Human Models


The drug development process l.jpg
The Drug Development Process

Is it safe?

Does it work?

Compound X

How much?

How often?

How should it be put

into the body?How long does it stay there?

Are the effects: short and long?

Does it leave the body? How?

Does the body change it? How?

Do other variables matter?

  • Safety and Efficacy


Primedica nonclinical contract research l.jpg
Primedica: Nonclinical Contract Research

CRO

Contract Research Organization

  • We test drugs, biologics, and medical devices in animalsto prove they are safe and effectivebefore they are tested in people.


Our product the final report l.jpg
Our Product: The Final Report

  • Attract client

  • Collaborate on study design

  • Schedule study

  • Order/quarantine animals

  • Receive/Store/Formulate Test Article

  • Dose Administration

  • Sample Collection

  • Process Samples

  • Euthanasia/Slide Preparation

  • Tissue Pathology

  • Deliver the Final Report


Who regulates animal use in research l.jpg
Who Regulates Animal Use in Research?

USDA United States Department of Agriculture

NIH National Institutes of Health

IACUC Institutional Care and Use Committee

The State Massachusetts Department of Public Health

Massachusetts Society for Prevention of Cruelty to Animals

AAALAC Association for Assessment and Accreditation of

Laboratory Animal Care International


Ethical issues in animal research l.jpg
Ethical Issues In Animal Research

  • Animals As Machines

    • Greek/Roman games

  • God Granted Dominion

    • Humane Stewardship

  • Rationality and a Soul

    • “the question is not Can they reason? nor Can they talk? but, Can they suffer?”

  • Speciesism

    • prejudiced in favor of one’s own kind


Differentiate between l.jpg
Differentiate Between. . .

Remember This!

  • Animal Welfare

    • The humane care and use of animals.

  • Animal Rights

    • The belief that animal rights are equal to human rights.“A rat is a dog is a boy.”


Some animals for some research l.jpg
Some Animals For Some Research

  • Reduce: Fewer Animals - Same Valid Results

    • Animal as it’s own control

    • Statistical analysis

    • Same animal for more than one study (necropsy)

  • Refine: Improve Procedures - Reduce Discomfort

    • Intrabladder catheter / regular urinary catheter

    • Vascular access port

  • Replace: Models Without Animals

    • Harvesting rabbit corneal cells

    • Bioreactor


  • Iacuc s role l.jpg
    IACUC’s Role

    • Reduce study duplication

    • Reduce animal discomfort

    • Justify species/number selection

    • Assure veterinary care

    • Ethical Guidelines

    • Membership

    • Meetings/Subcommittees

    • Semiannual Inspections/Program Reviews

    • Suspension


    Animal welfare concerns l.jpg
    Animal Welfare Concerns

    Remember This!

    • PREVENT/RECOGNIZE/REPORT

    • Report to a Group Leader, Supervisor, Manager, Study Director, IACUC Member, Vet, or HR

    • They notify IACUC/Attending Vet, in writing.

    INVESTIGATE/REPORT

    The company must investigate/report to the IACUC. IACUC

    will review the response and investigate too. IACUC will

    report findings/recommendations to the Institutional Official.

    RESOLVE/TAKE ACTION

    The outcome is variable, but serious violations (abuse, neglect) will result in termination(s).


    ad