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RECRUITMENT TALK. Remember There are few positions and many candidates 200-500 candidates for any tenure track faculty position 10 qualified people for each position I receive 30-50 unsolicited requests per month Step 1: Getting the Interview CV and personal statement

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RECRUITMENT TALK

Remember

There are few positions and many candidates

200-500 candidates for any tenure track faculty position

10 qualified people for each position

I receive 30-50 unsolicited requests per month

Step 1: Getting the Interview

CV and personal statement

Review standard University CV formats

I do not care what you think your skills are

I want to know what you have produced

I want to know what your training is

I will respond better to what I am used to seeing


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RECRUITMENT TALK

  • What am I looking for in a trainee candidate

  • What am I looking for in a faculty candidate


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RECRUITMENT TALK

  • You only get one chance to make a first impression

    • Arrive early

    • Dress Professionally

      • Males Tie and Jacket

      • Females Consider a suit

        • At least a dress or skirt.

      • Live with your clothes. Do not fidget

      • I am looking for a professional colleague

    • Slides must be clear, single format


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RECRUITMENT TALK

  • What am I looking for in a trainee candidate

    • Career goals

      • What do you want to do in 5 years

      • How will you get there:

      • What are your strengths and weaknesses

      • Are you driven to succeed

    • Talk

      • Organization

      • Thought process

      • Much more important than the data

      • Handling questions more important than the talk

        • NEVER EVER INTERRUPT

    • I am making a commitment to your career

      • Will you be successful

      • Are you teachable

      • Do you want to learn or do you already know it all


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RECRUITMENT TALK

  • What am I looking for in a Faculty Candidate

    • Someone I trust

      • Represent me in meetings

      • Not cause problems in and for the department

      • A team player and collaborator: Team sports

      • There is no “I” in a talk

    • Someone I want to work with, go to dinner with, go to meetings with

    • Someone who will make me better or my life easier

      • Will they teach classes well

    • Will they get grants

    • Are they going to be a good teacher

    • Are they intellectually curious; Will they listen to my questions. Will they review my grant and help me

    • Have they asked their supervisor about the project and what they can take with them


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RECRUITMENT TALK

  • There are many candidates.

  • Recruitment is occasional.

  • For students, we are looking at being

    • together for 4-6 years, PDFs 3-4 years, faculty a lifetime.

  • Divorce (termination) is painful

  • Estimated cost of a “wrong” faculty rectruitment: 750K

  • There are many ways to make a mistake, few to make a good first impression

  • Better to recruit no one than the wrong one


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RECRUITMENT TALK

3 PARTS

Scientific Presentation

One on one interviews

Dinner


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RECRUITMENT TALK

PREPARATION FOR THE TRIP

Its not all about the talk

DO YOUR HOMEWORK.

Institution

If you are going to Duke, know about the basketball team

If you are going to UT, know about the football team

Texas A and M, know what an Aggie is.

People

Study your agenda

Know who you are meeting.

Review online.

What is their latest paper. Know their history

Many people have websites or lab websites

IL2, LAKs and TILs

Know who you are going to dinner with


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RECRUITMENT TALK

TALK

Prepare practice and give it to as many people who will listen

Have people look at slides

Spelling errors, too busy

Use SpellCheck

PDF presentation is safest approach

Do not tell jokes or try to be funny.

You can have an amusing slide

NO motion slides unless absolutely necessary

If possible overlay slides if motion needed


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RECRUITMENT TALK

THE TALK

Expect to be nervous

Where to stand

Your slides can be crutches.

Do not read your slides but they are there if you need them

Speak slowly and clearly

If you get lost, do not panic. Take a deep breath and start again.

Make clear transitions. A few second gap is OK.

Tell one or maybe two stories well, not many.

Do not assume anyone has read your favorite papers including your own.


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RECRUITMENT TALK

THE TALK

  • Every slide should have a message and a reason to be in the talk

  • Tell a story. The talk should have a beginning middle and end.

    • Place the topic in context

      • Big picture

    • Logic flow: A set of slides showing what you will present: Fade in an out.

    • Results

    • Conclusion

    • Appropriate amount of time

      • 45 minutes


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RECRUITMENT TALK

  • THE TALK

    • Are you logical

    • Are you careful

    • Acknowledge anyone who did the work on the slide

    • Introduction

      • Put the topic in context

        • Enough background so people understand the question

        • What is the question

        • Why is this important


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RECRUITMENT TALK

  • The four slide cassette

    Introduction slide

    Set the question

    Present a model describing the question

    A picture is worth a thousand words!

    Method slide

    What was done and why

    Explain the approach and why

    Data slide

    Make a new slide for the talk with key points only

    NOT from your paper

    Controls are critical

    Are you careful.

    Conclusion/transition slide

    What does the data show you

    Go back to your model

    Present a revised model slide

    What is the next question

    Set the next cassette


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RECRUITMENT TALK

  • THE END

  • What have you learned

  • What are the next questions

  • One and maybe two slides

    • What would the title of your grant application be

    • What is the model

    • What are the aims


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RECRUITMENT TALK

  • THE DREADED DINNER

    • Do not drink AT ALL

      • It is too easy to sip too many times.

      • If they order you a drink or a glass of wine pick it up put it to your lips occasionally and do not drink

    • Think about what you order

      • Order a salad

      • Main course should be easy to eat

      • Skip desert

      • Only order coffee after others

      • DO NOT order spaghetti.

    • Do not discuss politics or religion unless asked and then say little and try to change the topic

    • Nobody cares about how they do things at home

    • You must participate

    • People like to talk about themselves

      • Where are they from. How did they get to the institution. Why did they come

    • Try to sit next to someone you know or the recruit leader

    • The Dinner is not a time to ask contentious questions


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THE OFFER

  • Review carefully

  • Ask questions but not too many

    • No one wants to work with someone who is a pain

  • Your best chance to negotiate is up front

    • No one wants to work with someone who is not excited about the job. Too much negotiation will lose the job

  • Produce and renegotiate

  • Produce and move elsewhere


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WHAT GOES AROUND COMES AROUND: MULTIPLE GENOMIC AMPLICONS TARGET VESICLE RECYCLING AND BIOENERGETICS

Joe Gray William Muller Jim Norman

Gordon B. Mills

Department of Systems Biology


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15 years of fishing in the genome pool TARGET VESICLE RECYCLING AND BIOENERGETICS

FISHING CAN WORK IF YOU USE THE RIGHT BAIT

JOE GRAY LBL AND FRIEND


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Early Stage Breast Cancer Resource TARGET VESICLE RECYCLING AND BIOENERGETICS(2408 tumors Stage 1,2 paraffin n= 971 MIP arrays) Decision tree analysis

*

*

*

*

*

*

*

*

*

*

Melissa Bondy, Patricia Thompson, Spyros Tsavichidis


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GENOMIC ABERRATIONS TARGET ENDOCYTOSIS AND POLARITY TARGET VESICLE RECYCLING AND BIOENERGETICS

PKCi

PIK3CA

MDS1 EVI1

Mir

PVT1

Myc

ERBB2

Grb7

Rab11FIP1

RCP

Cyclin D1

ZNF217

Rab25



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RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS CANCER

Rab25 is expressed in ER positive and HER2 positive, low in basal, absent in Claudin low

Ju-Seog Lee

Fan Zhang


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RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS CANCER

Ju-Seog Lee

Fan Zhang


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RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS

Polarity

Proliferation

Migration

Invasiveness

Apoptosis

Cargoes

Integrins

Gluts

EGFR family

Transferrin

RECYCLING

Specific Signaling Complexes

DECISION

DEGRADATION

Jim Norman


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RAB25 AND RCP REGULATE MOTILITY AND INVASION THROUGH SPATIALLY RESTRICTED RECYCLING AND LOCALIZED SIGNALING

Jim Norman


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Rab25 drives extension of invasive pseudopods SPATIALLY RESTRICTED RECYCLING AND LOCALIZED SIGNALING

  • Rab25/a5b1 compartment is located near the tip

GFP-a5 integrin

Cherry-Rab25

N

Patrick Caswell/Heather Spence


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RAB25 INTERACTS WITH EGFR SPATIALLY RESTRICTED RECYCLING AND LOCALIZED SIGNALING

Roshan Agarwal Kwai Wa Cheng


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RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS

Polarity

Proliferation

Migration

Invasiveness

Apoptosis

Cargoes

Integrins

Gluts

EGFR family

Transferrin

RECYCLING

Specific Signaling Complexes

DECISION

RAB25 includes a sequence change found in mutant RAS and should be GTP bound

Dominant active Rab11 family member

Rab25 preferentially binds RCP and integrins in presence of Rab11

DEGRADATION

RAB11 GDP

RAB25 GTP


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RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS

Polarity

Proliferation

Migration

Invasiveness

Apoptosis

Cargoes

Integrins

Gluts

EGFR family

Transferrin

RECYCLING

Specific Signaling Complexes

DECISION

RAS

AKT

Raf

Mek

GSK3

TGFb

signaling

DEGRADATION

MAPK


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RAB25 AND RCP EXIST AS A HETEROTETRAMERIC COMPLEX PLEIOMORPHIC FUNCTIONS

Greg Verdine Stapled peptides

Rab25

Rab25

RCP

RCP


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RAB25 INTERACTION NET: PLEIOMORPHIC FUNCTIONSReMTH, Yeast two hybrid, ip Mass Spec, Lumiere, Literature, STRING

GLUT1

Actin capping protein

Integrina5 b1

RCP

EGFR

AKT

TGFbR1

Igor Jurisica, Roshan Agarwal, Zhiyong Ding, Kwai Wa Cheng, Jim Norman


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RAB25 TRANSCRIPTOME IMPLICATES RAB25 IN BIOENERGETICS PLEIOMORPHIC FUNCTIONS

53-gene signature

Roshan Agarwal Kwai Wa Cheng


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GLYCOGEN IS A POTENTIAL ENERGY SOURCE PLEIOMORPHIC FUNCTIONS

AKT

GSK3

Rab

25

GPI


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ATP and GLYCOGEN ARE INCREASED BY RAB25 PLEIOMORPHIC FUNCTIONS

Kwai Wa Cheng


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GLYCOGEN STORES CONTRIBUTE TO THE ABILITY OF RAB25 TO MAINTAIN ATP LEVELS

Rab

25

Roshan Agarwal Kwai Wa Cheng


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Mechanisms of action of Rab25 MAINTAIN ATP LEVELS


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COLLABORATORS MAINTAIN ATP LEVELS

MILLS LAB Joe Gray LBL

Rab25

Kwai Wa Cheng Bill Muller McGill Canada

Roshan Agarwal

Sofie Claerhout Jim Norman Beatson Scotland

Yiling Lu

Qinghua Yu Igor Jurisica University of Toronto

Shuangxing Yu

Shreya Mitra

ReMTH

Zhiyong Ding Robert Bast MD Anderson

Bioenergetics Ju Seog Lee MD Anderson

Jae Ho Cheong

Jiyong Liang

RPPA/PI3K/Patient samples outcomes

Yiling Lu

Bryan Hennessy

Ana Gonzalez

Mark Carey

Fan Zhang


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MDACC MAINTAIN ATP LEVELSSan Francisco Joe Gray Wenlin Kuo

Ju-Seog Lee Prahlad RamBoston Joan Brugge Levi Garraway

Gabor Balazsi John Albeck Yoko Irie

Shiaw-Yih “Phoebus” Lin St. Louis Chuck Perou

Georg Halder Vanderbilt Carlos Arteaga

Gabriel Hortobagyi UBC Sam Aparicio David Huntsman

Funda Meric-Bernstam Baylor Zhou “Sunny” Songyang

Robert Bast Cheryl Walker Powel Brown Adrian Lee Jenny Chang

Steve Kornblau Holland Rene Bernards

Melissa Bondy John Heymach Norway Anne-Lise Boerresen-Dale

Michael Andreeff Therese Sorlie

Eric Jonasch Spain Jose Baselga Ana Lluch

Tissue Bank

Ayesegul Sahin Toronto Patricia Shaw Heather Begley

Karen Lu Ignacio Wistuba San Francisco Karen Smith McCune

Rosemarie Schmandt

BioinformaticsToronto Igor Jurisica

Kevin Coombes John Weinstein San Francisco Paul Spellman, William Gibb

Jonas Almeida Keith Baggerly Sach Murkherjee

Mandri Obeyesekere GSK/Semafore/Abbott/Exelixis/Keryx

COLLABORATORS


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