The Evolution of Biotechnology as a Knowledge Industry:
Download
1 / 37

The Evolution of Biotechnology as a Knowledge Industry: - PowerPoint PPT Presentation


  • 213 Views
  • Uploaded on

The Evolution of Biotechnology as a Knowledge Industry: Network Movies and Dynamic Analyses of Emergent Structure.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' The Evolution of Biotechnology as a Knowledge Industry: ' - LeeJohn


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Slide1 l.jpg
The Evolution of Biotechnology as a Knowledge Industry: Network Movies and Dynamic Analyses of Emergent Structure

  • Walter W. Powell Douglas R. White Kenneth W. KoputStanford University UC Irvine University of Arizona Slides by Douglas R. White

  • Biotechnology as a knowledge-based industry involves extensive reliance on organizational learning. This occurs through networks of dense collaborative ties among organizations. We model the emergence of the industry networkof contractual collaborations from 1988-99 in relation to both firm-level organizational and financial changes.


Network movie 1988 99 l.jpg
Network Movie: 1988-99

  • The following twelve slides show the evolution of collaborative contracts within the biotech industry

  • Green ties =Finance

  • Red ties =Res&Dev

    • Grey =Finance

    • LiteBlue =Biotech

    • Yellow =Pharmaceuticals

    • Orange =Res.Labs and Universities

    • DarkBrown =Government (e.g., NIH)

    • Pink =Miscellaneous


Slide3 l.jpg

1988: Lots of

Finance,

little R&D


Slide4 l.jpg

1989: Nucleus of

R&D attracts

more Finance


Slide5 l.jpg

1990: Massive

investment

in R&D


Slide6 l.jpg

1991: The phase

transition

is complete










Slide15 l.jpg

Figure 1: Levels of Network Cohesion: Tricomponents (within dark/red circles) embedded in Bicomponents (circled in medium/green) within Components (in light/yellow circles)




Figure 4 degree 1 distributions for the 1 mode data l.jpg
Figure 4: Degree(+1) Distributions for the 1-Mode Data


Figure 5 a degree 1 distributions for the 2 mode data l.jpg
Figure 5 a: Degree(+1) Distributions for the 2-Mode Data


Figure 5 b degree 1 distributions for the 2 mode data removing zero frequency counts l.jpg
Figure 5 b : Degree(+1) Distributions for the 2-Mode Data(removing zero frequency counts)


Slide21 l.jpg
Figure 5 c: Exponential for DBFs' degree choosing partners; power-law for partners degree chosen by DBFs


Slide22 l.jpg

Figure 6: power-law for partners degree chosen by DBFsScatterplot of Biotech degree as chosen by other Biotechs (1-Mode) and as chosers of 2-Mode Partners (v2log=.55+0.52v1og; R-Square=0.15)


Slide23 l.jpg

Figure 7: The power-law for partners degree chosen by DBFsSexta-component of R&D and Finance Contracts in the Biotech Industry Blue=Biotech, Size of nodes reflects number of finance ties. Brown=government Orange=Research Institutes and Universities Yellow=Pharmaceuticals (f=DBF p=partners)


Slide24 l.jpg

Figure 7: The power-law for partners degree chosen by DBFsSexta-component of R&D and Finance Contracts in the Biotech Industry Blue=Biotech, Size of nodes reflects number of finance ties. Brown=government Orange=Research Institutes and UniversitiesYellow=Pharmaceuticals (f=DBF p=partners)


Figure 8 1988 l.jpg
Figure power-law for partners degree chosen by DBFs 8: 1988


Figure 8 1989 l.jpg
Figure power-law for partners degree chosen by DBFs 8: 1989


Figure 8 1990 l.jpg
Figure power-law for partners degree chosen by DBFs 8: 1990


Figure 8 1991 l.jpg
Figure power-law for partners degree chosen by DBFs 8: 1991


Slide29 l.jpg
Figure G1: Time Series of Growth Parameters: Mean Growth by Tie Activity, Separately for Form of Partners.


Slide30 l.jpg
Figure G2: Time Series of Growth Parameters: Mean Growth by Partner Form, Separately for Type of Activity.


Slide31 l.jpg
Figure G2: Time Series of Growth Parameters: Mean Growth by Partner Form, Separately for Type of Activity.


Slide32 l.jpg
Figure G1: Time Series of Growth Parameters: Mean Growth by Tie Activity, Separately for Form of Partners.

  • Left Figure Plots Coefficient of Variation over time for Modal Combinations: Magenta = R&D to Universities and NonProfits, Red = R&D to Government, Green= Finance to Financial, Cyan = Commercial to Biotech, Blue = Commercial to Pharmaceutical and Other For- Profit.

  • Right Figure Plots Coefficient of Variation for all remaining combinations with no color legend.


Figure 9 cycles of learning and organizational returns powell et al 1999 l.jpg
Figure 9: Cycles of Learning and Organizational Returns Tie Activity, Separately for Form of Partners.(Powell et al. 1999)

Legend 1. Ovals represent network properties, rectangles are performance and outcome measures, while rounded rectangles can be treated as either firm characteristics or outcomes.2. Shadowed components carry over from Powell et al. (1996).


Figure 10 a finance and r d networks of 2219 organizations 1988 1991 l.jpg
Figure Tie Activity, Separately for Form of Partners. 10 a: Finance and R&D networks of 2219 organizations 1988-1991


Figure 10 b finance and r d networks of 2219 organizations 1992 1995 l.jpg
Figure Tie Activity, Separately for Form of Partners. 10 b: Finance and R&D networks of 2219 organizations 1992-1995


Figure 10 c finance and r d networks of 2219 organizations 1996 1999 l.jpg
Figure Tie Activity, Separately for Form of Partners. 10 c: Finance and R&D networks of 2219 organizations 1996-1999


Figure 11 distance from nih r d and finance l.jpg
Figure Tie Activity, Separately for Form of Partners. 11: Distance from NIH: R&D and Finance


ad