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TREATMENT OF IRRITABLE BOWEL SYNDROME BY THE ZONE DIET

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TREATMENT OF IRRITABLE BOWEL SYNDROME BY THE ZONE DIET. Anthony J Dowell MB , BS , MSc , FACS , FRCS(C) Nanaimo Regional General Hospital. IRRITABLE BOWEL SYNDROME. Chronic functional disorder Symptoms well known Cause obscure Treatments unsatisfactory:

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treatment of irritable bowel syndrome by the zone diet

TREATMENT OFIRRITABLE BOWEL SYNDROMEBY THE ZONE DIET

Anthony J Dowell

MB,BS, MSc, FACS, FRCS(C)

Nanaimo Regional General Hospital

irritable bowel syndrome
IRRITABLE BOWEL SYNDROME
  • Chronic functional disorder
  • Symptoms well known
  • Cause obscure
  • Treatments unsatisfactory:

Prokinetic & antkinetic agents variably effective – suggests motility disorder neuronally or hormonally mediated.

slide5
1800: less than 1oz/day
  • 1900: 2oz/day
  • 1950: 5oz/day (3lb sugar beet, 24 apples)
  • 2000: 8oz/day (180 lb/year)
zone diet
ZONE DIET
  • Current healthy diets restrict sugar and refined carbohydrate
  • Human gut has not had time to adapt to carbohydrate load since agricultural and industrial revolution
  • Zone diet takes this a step further by using diet to tightly control blood levels of major hormones, principally insulin.
  • Insulin a storage hormone, stores incoming calories as fuel for future use (fat)
  • Zone diet aims to control insulin levels within a tight zone by allowing a fairly constant absorption of low-glycaemic carbohydrate
zone diet i b s
ZONE DIET & I.B.S.
  • PILOT STUDY– 1 year
  • 35 patients
  • All female, 35-75
  • Abd symptoms/pain, clinically IBS
  • TESTS – stepwise approach (Univ of Alberta)

- minimize, R/O other causes

constipation/diarrhea predominant pain

  • ZONE DIET - informed consent

- prospective

- randomized

- follow up complete

results
RESULTS
  • Compliance 26/35
  • Unchanged 0/26
  • Improved 10/26
  • Much Better 16/26
discussion
DISCUSSION
  • Numbers small, trend seems very apparent
  • No statistical analysis would be appropriate
  • Real or placebo effect?
  • Original observation
  • No other published literature linking diet or a hormonal mechanism with IBS
  • Crohn’s disease treated with growth hormone
  • Confirmatory studies underway Victoria
conclusions
CONCLUSIONS
  • Symptoms of IBS seem to improve by controlling production of GI hormones, principally insulin, by The Zone Diet.
  • IBS may be hormonally mediated in response to excess dietary sugar & refined carbohydrate.
  • This has not been suggested before.
  • The best treatment for the condition may be cheap and plentiful, and is called food.
  • Clinical trial would seem worthwhile to test this.
  • Fundamental research is planned.
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