New Zealand Perspectives of HPV vaccination and Genital Tract Neoplasia. Sept 2006 Peter Sykes. Hpv 16/186/11. Age 9-26 3 vaccinations. MERCK. cervarix. Hpv 16/18. Cervical cancer is an important cause of mortality and morbidity particularly in developing countries. .
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Sexual contact morbidity particularly in developing countries.
Acute hpv infection
Persistent hpv infection
Integration of hpv DNA
Accumulation of mutation
CancerHPV infection is an obligatory step in the development of cervical cancer
10 to 30 yrs
14.6 morbidity particularly in developing countries.
OthersPrevalence of HPV Types in Cervical Cancer
*A pooled analysis and multicenter case control study (N = 3607)
1. Muñoz N, Bosch FX, Castellsagué X, et al. Int J Cancer. 2004;111:278–285.
Subjects are counted once in each applicable endpoint category. A subject may appear in more than one category.
*Cases per 100 person years at risk.
n = received ≥ 1 vaccination; includes protocol violations; HPV 6, 11, 16 or 18 sero(-) and HPV 6, 11, 16 or 18 DNA(-) at Day 1; Cases counted starting one month post-dose 1
CWH colposcopy Clinc
hpv 6,11,18,16 pos
Proportion of cin3 or worse assc with16,18,6,11.
A population based strategy of HPV vaccination has the potential to significantly reduce the future incidence of cervical cancer and other HPV related genital tract cancers.
In 2001 189 new registrations of cervical cancer potential to significantly reduce the future incidence of cervical cancer and other HPV related genital tract cancers.
24 women anal, 42 vulval and 14 vaginal cancer.
Cervical screening must continue
The risk of cervical cancer in
screened women is very low