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The Autonomic Nervous System

The Autonomic Nervous System. Lesson 15. Autonomic N. S. Homeostasis Maintenance of steady internal state Effectors autonomous Smooth Muscle, Cardiac Muscle, Glands Psychoactive drugs autonomic effects common ~. Autonomic Subdivisions. Sympathetic Emergency, flight/fight

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The Autonomic Nervous System

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  1. The AutonomicNervous System Lesson 15

  2. Autonomic N. S. • Homeostasis • Maintenance of steady internal state • Effectors • autonomous • Smooth Muscle, Cardiac Muscle, Glands • Psychoactive drugs • autonomic effects common ~

  3. Autonomic Subdivisions • Sympathetic • Emergency, flight/fight • Parasympathetic • Conservation / vegetative ~

  4. Preganglionic neuron Postganglionic neuron Ganglion Autonomic N. S.: General Features Effector

  5. Autonomic N. S.: General Features Effector ACh • At ganglia • Nicotinic receptors • different than neuromuscular • antagonist: hexamethonium ~

  6. Autonomic N. S.: General Features Effector ACh • Neuroeffector junction • Different NT for each division ~

  7. Pharmacology of Autonomic NS • Preganglionic neuron • releases ACh • Different NT at effectors • sympathetic division: NE • parasympathetic division: ACh ~

  8. Sympatheticvs. Parasympathetic • Sympathetic • ganglia near spinal cord • interconnected  active together • long-lasting effects • Parasympathetic • ganglia near effector • discrete  active independently • transient effects • Antagonistic regulation ~

  9. Pre- Post- Smooth muscle Glands NE Adrenal Glands Parasympathetic Sympathetic ACh

  10. Sympathetic Arousal Syndrome • Fight or flight situations • Diffuse sympathetic activation • Adrenal glands • releases NE into blood • maintains sympathetic arousal • Parasympathetic rebound ~

  11. Effector Responses Effector SympatheticParasympathetic Heart +- Respiration +- Salivation +(putrid)+(profuse) GI -+ Sweat glands +no input Iris +(radial)+(sphincter) ~

  12. Autonomic N.S.: Summary • Parasympathetic • Conservation • Cholinergic • Discrete/short-lasting • Sympathetic • Emergency • Noradrenergic • Diffuse/long-lasting ~

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